Prospective study on microstructure in medication-naïve adolescents with first-episode major depressive disorder

Jong ha Lee, Su Hyuk Chi, Minsoo Ko, Minjae Song, Byung Joo Ham, Young Hoon Ko, Sang il Suh, Moon Soo Lee

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Background:: Major depressive disorder (MDD) is one of the most prevalent mental disorders during adolescence, and early diagnosis and treatment are important. We aimed to characterize the microstructure of the brain in medication-naïve adolescents with first-episode MDD. Methods:: Patients with MDD (N = 31) and healthy controls (N = 27) participated in this study and severity of depressive symptoms, duration of untreated depressive episode, demographic data, and diffuse tensor imaging data were collected. A comparative analysis of patients and healthy controls was performed, and the effect of medication on the brain`s integrity was investigated through comparison before and after 3 months of treatment in the patient group. Tract-based spatial statistics was used for diffusion tensor image analysis. Results:: In the patient group, functional anisotropy (FA) values were significantly higher at the genu of the corpus callosum, body of the corpus callosum, and right anterior corona radiata than in healthy controls. After 3 months of treatment, FA values were significantly decreased in the left anterior limb of the internal capsule, left posterior limb of the internal capsule, and left superior longitudinal fasciculus. Limitations:: The sample size is relatively small and 3-month treatment period was relatively short. Conclusion:: FA values of patients with MDD were increased compared to healthy controls and decreased after treatment. These results suggested that pharmacological treatments in the early stages of MDD might restore the brain`s integrity.

Original languageEnglish
Pages (from-to)268-275
Number of pages8
JournalJournal of Affective Disorders
Publication statusPublished - 2021 Oct 1

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (grant numbers grant numbers NRF-2014R1A1A2054904 and NRF- 2017R1D1A1B03028672).

Publisher Copyright:
© 2021


  • Adolescent
  • Depression
  • First-episode
  • Medication-naïve
  • Microstructure

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health


Dive into the research topics of 'Prospective study on microstructure in medication-naïve adolescents with first-episode major depressive disorder'. Together they form a unique fingerprint.

Cite this