Protective effect of astaxanthin on naproxen-induced gastric antral ulceration in rats

Jeong Hwan Kim, Young Sik Kim, Gwan Gyu Song, Jong Jae Park, Hyo Ihl Chang

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)


Frequently used for humans as non-steroidal anti-inflammatory drug, naproxen has been known to induce ulcerative gastric lesion. The present study investigated the in vivo protective effect of astaxanthin isolated from Xanthophyllomyces dendrorhous against naproxen-induced gastric antral ulceration in rats. The oral administration of astaxanthin (1, 5, and 25 mg/kg of body weight) showed a significant protection against naproxen (80 mg/kg of body weight)-induced gastric antral ulcer and inhibited elevation of the lipid peroxide level in gastric mucosa. In addition, pretreatment of astaxanthin resulted in a significant increase in the activities of radical scavenging enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. A histologic examination clearly proved that the acute gastric mucosal lesion induced by naproxen nearly disappeared after the pretreatment of astaxanthin. These results suggest that astaxanthin removes the lipid peroxides and free radicals induced by naproxen, and it may offer potential remedy of gastric ulceration.

Original languageEnglish
Pages (from-to)53-59
Number of pages7
JournalEuropean Journal of Pharmacology
Issue number1
Publication statusPublished - 2005 May 2

Bibliographical note

Copyright 2008 Elsevier B.V., All rights reserved.


  • Anti-ulcer drug
  • Astaxanthin
  • Gastric antral ulceration
  • Orogastric administration
  • Xanthophyllomyces dendrorhous

ASJC Scopus subject areas

  • Pharmacology


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