Protective effectiveness of inactivated hantavirus vaccine against hemorrhagic fever with renal syndrome

Jaehun Jung; Sung Jun Ko; Hong Sang Oh; Song Mi Moon; Jin Won Song; Kyungmin Huh

doi:10.1093/infdis/jiy037

Protective effectiveness of inactivated hantavirus vaccine against hemorrhagic fever with renal syndrome

Jaehun Jung
, Sung Jun Ko
, Hong Sang Oh
, Song Mi Moon
, Jin Won Song
, Kyungmin Huh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

As there is no effective treatment against hemorrhagic fever with renal syndrome (HFRS), the development of effective vaccine is important. An inactivated hantavirus vaccine (IHV) has been used in Korea, but there has been controversy regarding its effectiveness. We conducted a case-control study to evaluate the vaccine effectiveness (VE) of IHV against HFRS in the Korean military. Unadjusted and adjusted VEs of IHV were 59.1% and 58.9%, respectively. VE was higher in divisions with high incidence of HFRS (unadjusted VE, 71.4%; adjusted VE, 78.7%). Our study demonstrated the moderate effectiveness of IHV in high-risk populations residing in endemic area.

Original language	English
Pages (from-to)	1417-1420
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	217
Issue number	9
DOIs	https://doi.org/10.1093/infdis/jiy037
Publication status	Published - 2018 May 1

Bibliographical note

Publisher Copyright:
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Hantavirus
Hemorrhagic fever with renal syndrome
Vaccine

ASJC Scopus subject areas

General Medicine

Access to Document

10.1093/infdis/jiy037

Cite this

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title = "Protective effectiveness of inactivated hantavirus vaccine against hemorrhagic fever with renal syndrome",

abstract = "As there is no effective treatment against hemorrhagic fever with renal syndrome (HFRS), the development of effective vaccine is important. An inactivated hantavirus vaccine (IHV) has been used in Korea, but there has been controversy regarding its effectiveness. We conducted a case-control study to evaluate the vaccine effectiveness (VE) of IHV against HFRS in the Korean military. Unadjusted and adjusted VEs of IHV were 59.1\% and 58.9\%, respectively. VE was higher in divisions with high incidence of HFRS (unadjusted VE, 71.4\%; adjusted VE, 78.7\%). Our study demonstrated the moderate effectiveness of IHV in high-risk populations residing in endemic area.",

keywords = "Hantavirus, Hemorrhagic fever with renal syndrome, Vaccine",

author = "Jaehun Jung and Ko, \{Sung Jun\} and Oh, \{Hong Sang\} and Moon, \{Song Mi\} and Song, \{Jin Won\} and Kyungmin Huh",

year = "2018",

month = may,

day = "1",

doi = "10.1093/infdis/jiy037",

language = "English",

volume = "217",

pages = "1417--1420",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Protective effectiveness of inactivated hantavirus vaccine against hemorrhagic fever with renal syndrome

AU - Jung, Jaehun

AU - Ko, Sung Jun

AU - Oh, Hong Sang

AU - Moon, Song Mi

AU - Song, Jin Won

AU - Huh, Kyungmin

PY - 2018/5/1

Y1 - 2018/5/1

N2 - As there is no effective treatment against hemorrhagic fever with renal syndrome (HFRS), the development of effective vaccine is important. An inactivated hantavirus vaccine (IHV) has been used in Korea, but there has been controversy regarding its effectiveness. We conducted a case-control study to evaluate the vaccine effectiveness (VE) of IHV against HFRS in the Korean military. Unadjusted and adjusted VEs of IHV were 59.1% and 58.9%, respectively. VE was higher in divisions with high incidence of HFRS (unadjusted VE, 71.4%; adjusted VE, 78.7%). Our study demonstrated the moderate effectiveness of IHV in high-risk populations residing in endemic area.

AB - As there is no effective treatment against hemorrhagic fever with renal syndrome (HFRS), the development of effective vaccine is important. An inactivated hantavirus vaccine (IHV) has been used in Korea, but there has been controversy regarding its effectiveness. We conducted a case-control study to evaluate the vaccine effectiveness (VE) of IHV against HFRS in the Korean military. Unadjusted and adjusted VEs of IHV were 59.1% and 58.9%, respectively. VE was higher in divisions with high incidence of HFRS (unadjusted VE, 71.4%; adjusted VE, 78.7%). Our study demonstrated the moderate effectiveness of IHV in high-risk populations residing in endemic area.

KW - Hantavirus

KW - Hemorrhagic fever with renal syndrome

KW - Vaccine

UR - https://www.scopus.com/pages/publications/85050749672

U2 - 10.1093/infdis/jiy037

DO - 10.1093/infdis/jiy037

M3 - Article

C2 - 29373686

AN - SCOPUS:85050749672

SN - 0022-1899

VL - 217

SP - 1417

EP - 1420

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 9

ER -

Protective effectiveness of inactivated hantavirus vaccine against hemorrhagic fever with renal syndrome

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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