Protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model

Eunmi Kim; Dong Won Lee; Hae Chul Park; Dong Hwee Kim

doi:10.1016/j.ymgmr.2021.100783

Protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model

Eunmi Kim, Dong Won Lee, Hae Chul Park, Dong Hwee Kim

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Hearing impairment is one of the complications in diabetes mellitus; however, there are very few therapeutic studies on it. In this study, we investigated the protective effect of alpha-lipoic acid (ALA) on hearing loss in diabetic transgenic zebrafish and confirmed that ALA protects the loss of hair cells (HCs) caused by hyperglycemia. The data indicated that ALA has a protective effect on the damage to HCs in diabetic zebrafish.

Original language	English
Article number	100783
Journal	Molecular Genetics and Metabolism Reports
Volume	28
DOIs	https://doi.org/10.1016/j.ymgmr.2021.100783
Publication status	Published - 2021 Sept

Bibliographical note

Funding Information:
This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) ( NRF-2020R1F1A1069106 ).

Publisher Copyright:
© 2021

Keywords

Alpha-lipoic acid
Diabetes mellitus
Hair cell
Pancreatic β-cell
Zebrafish

ASJC Scopus subject areas

Molecular Biology
Genetics
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ymgmr.2021.100783

Cite this

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title = "Protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model",

abstract = "Hearing impairment is one of the complications in diabetes mellitus; however, there are very few therapeutic studies on it. In this study, we investigated the protective effect of alpha-lipoic acid (ALA) on hearing loss in diabetic transgenic zebrafish and confirmed that ALA protects the loss of hair cells (HCs) caused by hyperglycemia. The data indicated that ALA has a protective effect on the damage to HCs in diabetic zebrafish.",

keywords = "Alpha-lipoic acid, Diabetes mellitus, Hair cell, Pancreatic β-cell, Zebrafish",

author = "Eunmi Kim and Lee, {Dong Won} and Park, {Hae Chul} and Kim, {Dong Hwee}",

note = "Funding Information: This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) ( NRF-2020R1F1A1069106 ). Publisher Copyright: {\textcopyright} 2021",

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AU - Kim, Eunmi

AU - Lee, Dong Won

AU - Park, Hae Chul

AU - Kim, Dong Hwee

PY - 2021/9

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N2 - Hearing impairment is one of the complications in diabetes mellitus; however, there are very few therapeutic studies on it. In this study, we investigated the protective effect of alpha-lipoic acid (ALA) on hearing loss in diabetic transgenic zebrafish and confirmed that ALA protects the loss of hair cells (HCs) caused by hyperglycemia. The data indicated that ALA has a protective effect on the damage to HCs in diabetic zebrafish.

AB - Hearing impairment is one of the complications in diabetes mellitus; however, there are very few therapeutic studies on it. In this study, we investigated the protective effect of alpha-lipoic acid (ALA) on hearing loss in diabetic transgenic zebrafish and confirmed that ALA protects the loss of hair cells (HCs) caused by hyperglycemia. The data indicated that ALA has a protective effect on the damage to HCs in diabetic zebrafish.

KW - Alpha-lipoic acid

KW - Diabetes mellitus

KW - Hair cell

KW - Pancreatic β-cell

KW - Zebrafish

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VL - 28

JO - Molecular Genetics and Metabolism Reports

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ER -

Protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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