Protein conformational in higher order φ-ψ maps

Gregory E. Sims, In Geol Choi, Sung Hou Kim

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


We have mapped protein conformational space from two to seven residue lengths by employing multidimensional scaling on a data matrix composed of pair-wise angular distances for multiple φ-ψ values collected from high-resolution protein structures. The resulting global maps show clustering of peptide conformations that reveals a dramatic reduction of conformational space as sampled by experimentally observed peptides. Each map can be viewed as a higher order φ-ψ plot defining regions of space that are conformationally allowed.

Original languageEnglish
Pages (from-to)618-621
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number3
Publication statusPublished - 2005 Jan 18
Externally publishedYes


  • Global mapping
  • Global peptide conformational mapping
  • Multidimensional scaling
  • Ramachandran map

ASJC Scopus subject areas

  • General


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