Abstract
In three-dimensional numerical studies of the aorta, it is difficult to apply proper boundary conditions at the end of each major aortic branch because of interactions between blood and organs. Organs and body parts were assumed to be likened to cylindrically shaped porous media, so-called pseudo-organs, and treated in the computational domain as forms of hemodynamic resistance. Permeability functions were determined from two-dimensional axisymmetric computations of each aortic branch and these functions were then used in an unsteady three-dimensional simulation of the complete aorta. Substantially accurate cardiac output (5.91 L/min) and blood distributions to the major branches were predicted.
Original language | English |
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Pages (from-to) | 1063-1072 |
Number of pages | 10 |
Journal | Computers in Biology and Medicine |
Volume | 37 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2007 Aug |
Bibliographical note
Funding Information:Kyung Sun Professor of Korea University Medical School, was born in Seoul, Korea. He is a chief of Biomedical Engineering as well as a chair of Thoracic and Cardiovascular Surgery at Korea University. In 2003, he has founded Korea Artificial Organ Center which is funded by Ministry of Health of Korean government. His main clinical activities are adult cardiac surgery including CABG and valve operation, and the main research interests are artificial organs, especially artificial heart for either preclinical orclinical trial.
Funding Information:
This study was supported by the grant from the Korea Health 21 R&D Project of the Ministry of Health & Welfare (grant no. A020609) and the Brain Korea 21 Project of the Ministry of Education and Human Resources Development, Republic of Korea. C.Y. Park was supported by the Post-doctoral Fellowship Program of Korea Science & Engineering Foundation (KOSEF).
Keywords
- Aorta
- Blood interaction
- Hemodynamic resistance
- Numerical analysis
- Porous media
ASJC Scopus subject areas
- Computer Science Applications
- Health Informatics