Pulmonary fibrosis under chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin

Jin Yong Jung; Gyu Young Hur; Ki Hwan Jung; Hae Chul Jung; Sung Yong Lee; In Keun Choi; Sang Yeub Lee; Je Hyeong Kim; Jae Hong Seo; Chol Shin; Jae Jeong Shim; Kwang Ho In; Kyung Ho Kang; Se Hwa Yoo

doi:10.4046/trd.2005.59.5.536

Pulmonary fibrosis under chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin

Jin Yong Jung, Gyu Young Hur, Ki Hwan Jung, Hae Chul Jung, Sung Yong Lee, In Keun Choi, Sang Yeub Lee, Je Hyeong Kim, Jae Hong Seo, Chol Shin, Jae Jeong Shim, Kwang Ho In, Kyung Ho Kang, Se Hwa Yoo

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The combination of oxaliplatin, 5-fluorouracil and leucovorin (FOLFOX) has recently been shown to be beneficial in advanced colorectal and gastric cancers. The side effects of this regimen include neutropenia, diarrhea and neurosensory toxicity. However, case reports on the pulmonary toxicities of this regimen are very limited. Especially, the development of pulmonary fibrosis has never been cited in the literature. Herein is reported the case of a patient treated with oxaliplatin, 5 fluorouracil and leucovorin combination chemotherapy in whom pulmonary fibrosis developed, but which improved after steroid pulse therapy.

Original language	English
Pages (from-to)	536-540
Number of pages	5
Journal	Tuberculosis and Respiratory Diseases
Volume	59
Issue number	5
DOIs	https://doi.org/10.4046/trd.2005.59.5.536
Publication status	Published - 2005 Nov

Keywords

Chemotherapy
Fluorouracil
Leucovorin
Oxaliplatin
Pulmonary fibrosis

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4046/trd.2005.59.5.536

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title = "Pulmonary fibrosis under chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin",

abstract = "The combination of oxaliplatin, 5-fluorouracil and leucovorin (FOLFOX) has recently been shown to be beneficial in advanced colorectal and gastric cancers. The side effects of this regimen include neutropenia, diarrhea and neurosensory toxicity. However, case reports on the pulmonary toxicities of this regimen are very limited. Especially, the development of pulmonary fibrosis has never been cited in the literature. Herein is reported the case of a patient treated with oxaliplatin, 5 fluorouracil and leucovorin combination chemotherapy in whom pulmonary fibrosis developed, but which improved after steroid pulse therapy.",

keywords = "Chemotherapy, Fluorouracil, Leucovorin, Oxaliplatin, Pulmonary fibrosis",

author = "Jung, {Jin Yong} and Hur, {Gyu Young} and Jung, {Ki Hwan} and Jung, {Hae Chul} and Lee, {Sung Yong} and Choi, {In Keun} and Lee, {Sang Yeub} and Kim, {Je Hyeong} and Seo, {Jae Hong} and Chol Shin and Shim, {Jae Jeong} and In, {Kwang Ho} and Kang, {Kyung Ho} and Yoo, {Se Hwa}",

year = "2005",

month = nov,

doi = "10.4046/trd.2005.59.5.536",

language = "English",

volume = "59",

pages = "536--540",

journal = "Tuberculosis and Respiratory Diseases",

issn = "1738-3536",

publisher = "The Korean Academy of Tuberculosis and Respiratory Diseases",

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T1 - Pulmonary fibrosis under chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin

AU - Jung, Jin Yong

AU - Hur, Gyu Young

AU - Jung, Ki Hwan

AU - Jung, Hae Chul

AU - Lee, Sung Yong

AU - Choi, In Keun

AU - Lee, Sang Yeub

AU - Kim, Je Hyeong

AU - Seo, Jae Hong

AU - Shin, Chol

AU - Shim, Jae Jeong

AU - In, Kwang Ho

AU - Kang, Kyung Ho

AU - Yoo, Se Hwa

PY - 2005/11

Y1 - 2005/11

N2 - The combination of oxaliplatin, 5-fluorouracil and leucovorin (FOLFOX) has recently been shown to be beneficial in advanced colorectal and gastric cancers. The side effects of this regimen include neutropenia, diarrhea and neurosensory toxicity. However, case reports on the pulmonary toxicities of this regimen are very limited. Especially, the development of pulmonary fibrosis has never been cited in the literature. Herein is reported the case of a patient treated with oxaliplatin, 5 fluorouracil and leucovorin combination chemotherapy in whom pulmonary fibrosis developed, but which improved after steroid pulse therapy.

AB - The combination of oxaliplatin, 5-fluorouracil and leucovorin (FOLFOX) has recently been shown to be beneficial in advanced colorectal and gastric cancers. The side effects of this regimen include neutropenia, diarrhea and neurosensory toxicity. However, case reports on the pulmonary toxicities of this regimen are very limited. Especially, the development of pulmonary fibrosis has never been cited in the literature. Herein is reported the case of a patient treated with oxaliplatin, 5 fluorouracil and leucovorin combination chemotherapy in whom pulmonary fibrosis developed, but which improved after steroid pulse therapy.

KW - Chemotherapy

KW - Fluorouracil

KW - Leucovorin

KW - Oxaliplatin

KW - Pulmonary fibrosis

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U2 - 10.4046/trd.2005.59.5.536

DO - 10.4046/trd.2005.59.5.536

M3 - Article

AN - SCOPUS:33644862706

SN - 1738-3536

VL - 59

SP - 536

EP - 540

JO - Tuberculosis and Respiratory Diseases

JF - Tuberculosis and Respiratory Diseases

IS - 5

ER -

Pulmonary fibrosis under chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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