Putative association between UBE2E2 polymorphisms and the risk of gestational diabetes mellitus

Jason Y. Kim; Hyun Sub Cheong; Byung Lae Park; Sei Hyun Baik; Sunmin Park; Seogho Kim; Hyoung Doo Shin; Sung Hoon Kim

doi:10.3109/09513590.2013.813465

Putative association between UBE2E2 polymorphisms and the risk of gestational diabetes mellitus

Jason Y. Kim, Hyun Sub Cheong, Byung Lae Park, Sei Hyun Baik, Sunmin Park, Seogho Kim, Hyoung Doo Shin, Sung Hoon Kim

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

We hypothesized that ubiquitin-conjugating enzyme E2 E2 (UBE2E2) may be associated with gestational diabetes mellitus (GDM) and conducted association analyses. A total of 2071 subjects were recruited for the study, with 1104 cases and 967 controls. Two UBE2E2 single-nucleotide polymorphisms rs6780569 and rs7612463, and their haplotypes were analyzed for the study. As a result, rs7612463 showed a significant association with GDM in the recessive model. In addition, the regression analyses for the phenotypes showed that rs6780569. rs7612463 and ht2 showed significant associations with fasting plasma glucose (FPG) in recessive models, while ht1 showed an association in the dominant model. Our results show that the genetic variants of UBE2E2 are associated with GDM and FPG, which could be an important preliminary result for future studies.

Original language	English
Pages (from-to)	904-908
Number of pages	5
Journal	Gynecological Endocrinology
Volume	29
Issue number	10
DOIs	https://doi.org/10.3109/09513590.2013.813465
Publication status	Published - 2013 Oct
Externally published	Yes

Bibliographical note

Funding Information:
This study was supported by Korean Research Foundation (R04-2008-000-10078-0); the Korea Science and Engineering Foundation (KOSEF) funded by the Korean government (MEST) (No. 2009-0080157); and the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (Grant No. A102065-1011-1070100).

Keywords

Gestational diabetes mellitus
Haplotype
Single-nucleotide polymorphism
Ubiquitin-conjugating enzyme E2 E2

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Obstetrics and Gynaecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/09513590.2013.813465

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title = "Putative association between UBE2E2 polymorphisms and the risk of gestational diabetes mellitus",

abstract = "We hypothesized that ubiquitin-conjugating enzyme E2 E2 (UBE2E2) may be associated with gestational diabetes mellitus (GDM) and conducted association analyses. A total of 2071 subjects were recruited for the study, with 1104 cases and 967 controls. Two UBE2E2 single-nucleotide polymorphisms rs6780569 and rs7612463, and their haplotypes were analyzed for the study. As a result, rs7612463 showed a significant association with GDM in the recessive model. In addition, the regression analyses for the phenotypes showed that rs6780569. rs7612463 and ht2 showed significant associations with fasting plasma glucose (FPG) in recessive models, while ht1 showed an association in the dominant model. Our results show that the genetic variants of UBE2E2 are associated with GDM and FPG, which could be an important preliminary result for future studies.",

keywords = "Gestational diabetes mellitus, Haplotype, Single-nucleotide polymorphism, Ubiquitin-conjugating enzyme E2 E2",

author = "Kim, {Jason Y.} and Cheong, {Hyun Sub} and Park, {Byung Lae} and Baik, {Sei Hyun} and Sunmin Park and Seogho Kim and Shin, {Hyoung Doo} and Kim, {Sung Hoon}",

note = "Funding Information: This study was supported by Korean Research Foundation (R04-2008-000-10078-0); the Korea Science and Engineering Foundation (KOSEF) funded by the Korean government (MEST) (No. 2009-0080157); and the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (Grant No. A102065-1011-1070100).",

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doi = "10.3109/09513590.2013.813465",

language = "English",

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AU - Kim, Jason Y.

AU - Cheong, Hyun Sub

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AU - Baik, Sei Hyun

AU - Park, Sunmin

AU - Kim, Seogho

AU - Shin, Hyoung Doo

AU - Kim, Sung Hoon

N1 - Funding Information: This study was supported by Korean Research Foundation (R04-2008-000-10078-0); the Korea Science and Engineering Foundation (KOSEF) funded by the Korean government (MEST) (No. 2009-0080157); and the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (Grant No. A102065-1011-1070100).

PY - 2013/10

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N2 - We hypothesized that ubiquitin-conjugating enzyme E2 E2 (UBE2E2) may be associated with gestational diabetes mellitus (GDM) and conducted association analyses. A total of 2071 subjects were recruited for the study, with 1104 cases and 967 controls. Two UBE2E2 single-nucleotide polymorphisms rs6780569 and rs7612463, and their haplotypes were analyzed for the study. As a result, rs7612463 showed a significant association with GDM in the recessive model. In addition, the regression analyses for the phenotypes showed that rs6780569. rs7612463 and ht2 showed significant associations with fasting plasma glucose (FPG) in recessive models, while ht1 showed an association in the dominant model. Our results show that the genetic variants of UBE2E2 are associated with GDM and FPG, which could be an important preliminary result for future studies.

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Putative association between UBE2E2 polymorphisms and the risk of gestational diabetes mellitus

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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