Abstract
A new dihydropyranocoumarin, (+)-cis-(3′S,4′S)- diisobutyrylkhellactone (1), together with five known compounds, 3′-senecioyl-4′-acetylkhellactone (2), 3′-isovaleryl-4′- acetylkhellactone (3), 3′,4′-disenecioylkhellactone (4), 3′-isovaleryl-4′-senecioylkhellactone (5), and 3′,4′- diisovalerylkhellactone (6), was isolated from Glehnia littoralis. Their chemical structures were elucidated based on the spectroscopic data interpretation, particularly 1D and 2D NMR data including HMQC and HMBC. All the isolated compounds showed the potential to inhibit LPS-induced nitric oxide production in RAW 264.7 cells with IC50 values ranging from 7.4 to 44.3 μM.
| Original language | English |
|---|---|
| Pages (from-to) | 2717-2719 |
| Number of pages | 3 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 24 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2014 Jun 15 |
Bibliographical note
Funding Information:This research was supported financially by the Medical Research Center Program ( MRC, 2008-0062275 ) through the National Research Foundation of Korea and the Ministry of Trade, Industry & Energy ( MOTIE, 1415126993 ) through the fostering project of Osong Academy-Industry Convergence (BAIO). The authors thank the Center for Research Instruments and Experimental Facilities, Chungbuk National University for providing the NMR spectroscopic measurements.
Keywords
- Apiaceae
- Dihydropyranocoumarin
- Glehnia littoralis
- Nitric oxide production inhibitor
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry