Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells

Seong Su Hong, Seon A. Lee, Nahyun Kim, Ji Sang Hwang, Xiang Hua Han, Mi Kyeong Lee, Jae Kyung Jung, Jin Tae Hong, Youngsoo Kim, Dongho Lee, Bang Yeon Hwang

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

A new pyrrolidinone diterpenoid, excisusin F (1), was isolated from the aerial parts of Isodon excisus (Lamiaceae), together with four known compounds, and their structures were determined mainly by NMR (1D and 2D) and mass spectrometry. Excisusin F (1) and inflexarabdonin E (3) showed potent inhibitory effects of LPS-induced nitric oxide production in RAW264.7 cells with the IC50 value of 10.4 and 3.8 μM, respectively.

Original languageEnglish
Pages (from-to)1279-1281
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number4
DOIs
Publication statusPublished - 2011 Feb 15

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (MRC, 2010-0029480 ) and the grant of the Korean Ministry of Education, Science and Technology (The Regional Core Research Program/Chungbuk BIT Research-Oriented University Consortium). We thank the Korea Basic Science Institute for providing certain instruments used in this study.

Keywords

  • Isodon excisus
  • Lamiaceae
  • Nitric oxide inhibitor
  • Pyrrolidinone diterpenoid

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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