[Q fever as a cause of acute hepatitis accompanying fever].

Hyun Jung Lee, Ji Hoon Kim, Eileen L. Yoon, Young Sun Lee, Jong Eun Yeon, Kwan Soo Byun, Baek Hui Kim, Youngjoon Ryu

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Q fever is a zoonotic infection caused by Coxiella burnetti, which has been previously regarded as an uncommon infectious disease in Korea but is sporadically reported recently. Common manifestations of acute Q fever usually present as influenza-like illness, pneumonia and occasionally hepatitis. Herein, we report 4 cases of acute Q fever as a cause of acute hepatitis and fever. All patients had fever and non-specific symptoms, and laboratory test showed acute hepatitis. Antibody surveys for many virus infections and bacterial cultures were negative. Finally, they were diagnosed acute Q fever by an indirect microimmunofluorescence test. Liver biopsy in 3 patients revealed granuloma including one with typical fibrin-ring. All patients had complete resolution of symptoms and signs with doxycycline treatment. Q fever should be considered in the differential diagnosis of patients with fever of unknown origin with acute hepatitis in Korea.

Original languageEnglish
Pages (from-to)189-193
Number of pages5
JournalThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Issue number3
Publication statusPublished - 2011 Mar 25

ASJC Scopus subject areas

  • General Medicine


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