@inproceedings{a345f418d0b944459f7eeeec38607372,
title = "Quantitative analysis of the interactions between 3d hepatocyte tissue and capillary networks in a microfluidic platform",
abstract = "Tissue vascularization is one of the biggest challenges in tissue engineering. We constructed 3D hepatocyte tissue-like structures and endothelial capillary networks in a microfluidic platform. Here, we analyzed interactions between these structures quantitatively by recording the cell migration and morphogenesis. The analysis of capillary network extension rate under various combinations of growth factors (e.g., HGF, VEGF) revealed that the growth rate significantly increased by the growth factor addition. The capillary networks, however, stopped extending after contacting with hepatocytes, suggesting that additional factors are necessary for achieving hepatocyte tissue-like structures including microvascular networks.",
keywords = "Hepatocyte, Tissue Engineering, Vascularization",
author = "Tomohiro Tsuji and Seok Chung and Roger Kamm and Mariko Ikeda and Kazuo Tanishita and Ryo Sudo",
year = "2011",
language = "English",
isbn = "9781618395955",
series = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
pages = "1529--1531",
booktitle = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
note = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 ; Conference date: 02-10-2011 Through 06-10-2011",
}