Quantitative T2 mapping for detecting myocardial edema after reperfusion of myocardial infarction: Validation and comparison with T2-weighted images

Chul Hwan Park, Eui Young Choi, Hyuck Moon Kwon, Bum Kee Hong, Byoung Kwon Lee, Young Won Yoon, Pil Ki Min, Andreas Greiser, Mun Young Paek, Wei Yu, Yon Mi Sung, Sung Ho Hwang, Yoo Jin Hong, Tae Hoon Kim

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


This study evaluates the clinical usefulness of T2 mapping for the detection of myocardial edema in the re-perfused acute myocardial infarction (MI). Cardiac MRIs were reviewed in 20 patients who had acute MI after reperfusion therapy. The regional T2 values and T2- weighted image (T2WI) signal intensities (SI) were measured in the infarcted and remote zones of the myocardium. Patients were divided into three groups according to the signal patterns of the infarcted myocardium on the T2WIs. The T2 values of the infarcted zones were compared on the T2 maps among the three groups. Validation of the T2 values was performed in the normal myocardium of seven healthy volunteers. There were no significant differences in mean T2WI-SI or T2 values in the normal myocardium of healthy volunteers compared to the remote myocardium of acute MI patients (p>0.05). Mean SI on the T2WIs was significantly higher in the infarcted myocardium (81.3 ± 37.6) than in the remote myocardium (63.8 ± 18.1) (p < 0.05). The T2WIs showed high SI in ten patients (group 1), iso-SI in seven (group 2), and low SI in three (group 3) in the infarcted myocardium, compared to the remote myocardium. The T2 maps showed that T2 values in the infarcted myocardium had mostly increased, regardless of group, with values of 71 ± 9 ms in group 1, 64.9 ± 7.4 ms in group 2, and 61.4 ± 8.5 ms in group 3. T2 mapping is superior to T2WI for detecting areas of high SI in the infarcted myocardium. Therefore, quantitative T2 mapping sequences may be more useful and reliable in identifying myocardial edema in the infarcted myocardium than T2WI.

Original languageEnglish
Pages (from-to)65-72
Number of pages8
JournalInternational Journal of Cardiovascular Imaging
Issue number1 SUPPL.
Publication statusPublished - 2013 Jun

Bibliographical note

Funding Information:
Acknowledgments This work was supported by a faculty research grant of Yonsei University College of Medicine for 2011 (6-2011-0189, 6-2011-0190) and 2012 (6-2012-0072). This work was supported by the third Advanced School for Core Investigators from Asian Society of Cardiovascular Imaging 2012.


  • Edema
  • Magnetic resonance imaging
  • Myocardial infarction
  • T2 mapping

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Quantitative T2 mapping for detecting myocardial edema after reperfusion of myocardial infarction: Validation and comparison with T2-weighted images'. Together they form a unique fingerprint.

Cite this