Quercetin intake, MATE1 polymorphism, and metabolic syndrome in Korean population: Hallym aging study

Jung Eun Lee; Hye Won Park; Jae Kyung Lee; Bo Ram Mok; Hae Jeung Lee; Sung Joon Lee; Dong Hyun Kim

doi:10.1007/s10068-016-0271-8

Quercetin intake, MATE1 polymorphism, and metabolic syndrome in Korean population: Hallym aging study

Jung Eun Lee, Hye Won Park, Jae Kyung Lee, Bo Ram Mok, Hae Jeung Lee, Sung Joon Lee, Dong Hyun Kim

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Multidrug and toxic compound extrusion transporter-1 (MATE1) is a quercetin transporter. We examined the associations of quercetin intake and polymorphism of MATE1 in relation to metabolic syndrome (MetS) in Hallym Aging Study. Quercetin intake and the measurements for MetS were assessed in 2004. Six tagging single nucleotide polymorphisms (SNPs) at MATE1 gene were genotyped in 428 Korean adults in 2012. We found a lower prevalence of MetS with quercetin intake; compared to the lowest quartile, odds ratios (ORs, 95% confidence intervals; CIs) were 0.44 (0.24-0.84) for the 3^rd quartile. Individuals with the minor allele of MATE1, rs2453589, tended to have a lower prevalence of MetS compared to those with the major allele (OR=0.69; CI=0.36-1.34). However, interactions between quercetin intake and six MATE1 polymorphisms in relation to MetS were not significant (p for interaction ≥0.37). In conclusion, intake of quercetin was associated with MetS in Korean populations.

Original language	English
Pages (from-to)	1783-1788
Number of pages	6
Journal	Food Science and Biotechnology
Volume	25
Issue number	6
DOIs	https://doi.org/10.1007/s10068-016-0271-8
Publication status	Published - 2016 Dec 1

Keywords

flavonoid
metabolic syndrome
multidrug and toxic compound extrusion transporter-1
quercetin

ASJC Scopus subject areas

Biotechnology
Food Science
Applied Microbiology and Biotechnology

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title = "Quercetin intake, MATE1 polymorphism, and metabolic syndrome in Korean population: Hallym aging study",

abstract = "Multidrug and toxic compound extrusion transporter-1 (MATE1) is a quercetin transporter. We examined the associations of quercetin intake and polymorphism of MATE1 in relation to metabolic syndrome (MetS) in Hallym Aging Study. Quercetin intake and the measurements for MetS were assessed in 2004. Six tagging single nucleotide polymorphisms (SNPs) at MATE1 gene were genotyped in 428 Korean adults in 2012. We found a lower prevalence of MetS with quercetin intake; compared to the lowest quartile, odds ratios (ORs, 95% confidence intervals; CIs) were 0.44 (0.24-0.84) for the 3rd quartile. Individuals with the minor allele of MATE1, rs2453589, tended to have a lower prevalence of MetS compared to those with the major allele (OR=0.69; CI=0.36-1.34). However, interactions between quercetin intake and six MATE1 polymorphisms in relation to MetS were not significant (p for interaction ≥0.37). In conclusion, intake of quercetin was associated with MetS in Korean populations.",

keywords = "flavonoid, metabolic syndrome, multidrug and toxic compound extrusion transporter-1, quercetin",

author = "Lee, {Jung Eun} and Park, {Hye Won} and Lee, {Jae Kyung} and Mok, {Bo Ram} and Lee, {Hae Jeung} and Lee, {Sung Joon} and Kim, {Dong Hyun}",

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T2 - Hallym aging study

AU - Lee, Jung Eun

AU - Park, Hye Won

AU - Lee, Jae Kyung

AU - Mok, Bo Ram

AU - Lee, Hae Jeung

AU - Lee, Sung Joon

AU - Kim, Dong Hyun

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Multidrug and toxic compound extrusion transporter-1 (MATE1) is a quercetin transporter. We examined the associations of quercetin intake and polymorphism of MATE1 in relation to metabolic syndrome (MetS) in Hallym Aging Study. Quercetin intake and the measurements for MetS were assessed in 2004. Six tagging single nucleotide polymorphisms (SNPs) at MATE1 gene were genotyped in 428 Korean adults in 2012. We found a lower prevalence of MetS with quercetin intake; compared to the lowest quartile, odds ratios (ORs, 95% confidence intervals; CIs) were 0.44 (0.24-0.84) for the 3rd quartile. Individuals with the minor allele of MATE1, rs2453589, tended to have a lower prevalence of MetS compared to those with the major allele (OR=0.69; CI=0.36-1.34). However, interactions between quercetin intake and six MATE1 polymorphisms in relation to MetS were not significant (p for interaction ≥0.37). In conclusion, intake of quercetin was associated with MetS in Korean populations.

AB - Multidrug and toxic compound extrusion transporter-1 (MATE1) is a quercetin transporter. We examined the associations of quercetin intake and polymorphism of MATE1 in relation to metabolic syndrome (MetS) in Hallym Aging Study. Quercetin intake and the measurements for MetS were assessed in 2004. Six tagging single nucleotide polymorphisms (SNPs) at MATE1 gene were genotyped in 428 Korean adults in 2012. We found a lower prevalence of MetS with quercetin intake; compared to the lowest quartile, odds ratios (ORs, 95% confidence intervals; CIs) were 0.44 (0.24-0.84) for the 3rd quartile. Individuals with the minor allele of MATE1, rs2453589, tended to have a lower prevalence of MetS compared to those with the major allele (OR=0.69; CI=0.36-1.34). However, interactions between quercetin intake and six MATE1 polymorphisms in relation to MetS were not significant (p for interaction ≥0.37). In conclusion, intake of quercetin was associated with MetS in Korean populations.

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Quercetin intake, MATE1 polymorphism, and metabolic syndrome in Korean population: Hallym aging study

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Keywords

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