Abstract
Nine quinolone alkaloids (1 - 9) from the fruits of Evodia rutaecarpa were investigated for their inhibitory activity on nuclear factor of activated T cells (NFAT)-dependent transcription in comparison with nuclear factor (NF)-κB-dependent transcription using a reporter gene assay. These alkaloids showed inhibitory effects against NFAT activity, with IC50 values between 0.91 μM and 15.91 μM. Of the N-methylated quinolones, the longer aliphatic side chain at the quinolone ring showed stronger inhibition of NFAT activity. These N-methylated compounds showed comparable inhibitory effects against NF-κB activity. However, quinolone alkaloids without the N-methyl group showed a more selective inhibition of NFAT activity.
Original language | English |
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Pages (from-to) | 926-928 |
Number of pages | 3 |
Journal | Biological and Pharmaceutical Bulletin |
Volume | 27 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2004 Jun |
Externally published | Yes |
Keywords
- Evodia rutaecarpa
- Nuclear factor activated T cell
- Nuclear factor-κB
- Quinolone alkaloid
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science