Quinolone alkaloids with inhibitory activity against nuclear factor of activated T cells from the fruits of Evodia rutaecarpa

Hui Zi Jin; Jeong Hyung Lee; Dongho Lee; Hyun Sun Lee; Young Soo Hong; Young Ho Kim; Jung Joon Lee

doi:10.1248/bpb.27.926

Quinolone alkaloids with inhibitory activity against nuclear factor of activated T cells from the fruits of Evodia rutaecarpa

Hui Zi Jin, Jeong Hyung Lee, Dongho Lee, Hyun Sun Lee, Young Soo Hong, Young Ho Kim, Jung Joon Lee

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Nine quinolone alkaloids (1 - 9) from the fruits of Evodia rutaecarpa were investigated for their inhibitory activity on nuclear factor of activated T cells (NFAT)-dependent transcription in comparison with nuclear factor (NF)-κB-dependent transcription using a reporter gene assay. These alkaloids showed inhibitory effects against NFAT activity, with IC₅₀ values between 0.91 μM and 15.91 μM. Of the N-methylated quinolones, the longer aliphatic side chain at the quinolone ring showed stronger inhibition of NFAT activity. These N-methylated compounds showed comparable inhibitory effects against NF-κB activity. However, quinolone alkaloids without the N-methyl group showed a more selective inhibition of NFAT activity.

Original language	English
Pages (from-to)	926-928
Number of pages	3
Journal	Biological and Pharmaceutical Bulletin
Volume	27
Issue number	6
DOIs	https://doi.org/10.1248/bpb.27.926
Publication status	Published - 2004 Jun
Externally published	Yes

Keywords

Evodia rutaecarpa
Nuclear factor activated T cell
Nuclear factor-κB
Quinolone alkaloid

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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10.1248/bpb.27.926

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title = "Quinolone alkaloids with inhibitory activity against nuclear factor of activated T cells from the fruits of Evodia rutaecarpa",

abstract = "Nine quinolone alkaloids (1 - 9) from the fruits of Evodia rutaecarpa were investigated for their inhibitory activity on nuclear factor of activated T cells (NFAT)-dependent transcription in comparison with nuclear factor (NF)-κB-dependent transcription using a reporter gene assay. These alkaloids showed inhibitory effects against NFAT activity, with IC50 values between 0.91 μM and 15.91 μM. Of the N-methylated quinolones, the longer aliphatic side chain at the quinolone ring showed stronger inhibition of NFAT activity. These N-methylated compounds showed comparable inhibitory effects against NF-κB activity. However, quinolone alkaloids without the N-methyl group showed a more selective inhibition of NFAT activity.",

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author = "Jin, {Hui Zi} and Lee, {Jeong Hyung} and Dongho Lee and Lee, {Hyun Sun} and Hong, {Young Soo} and Kim, {Young Ho} and Lee, {Jung Joon}",

year = "2004",

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AU - Jin, Hui Zi

AU - Lee, Jeong Hyung

AU - Lee, Dongho

AU - Lee, Hyun Sun

AU - Hong, Young Soo

AU - Kim, Young Ho

AU - Lee, Jung Joon

PY - 2004/6

Y1 - 2004/6

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AB - Nine quinolone alkaloids (1 - 9) from the fruits of Evodia rutaecarpa were investigated for their inhibitory activity on nuclear factor of activated T cells (NFAT)-dependent transcription in comparison with nuclear factor (NF)-κB-dependent transcription using a reporter gene assay. These alkaloids showed inhibitory effects against NFAT activity, with IC50 values between 0.91 μM and 15.91 μM. Of the N-methylated quinolones, the longer aliphatic side chain at the quinolone ring showed stronger inhibition of NFAT activity. These N-methylated compounds showed comparable inhibitory effects against NF-κB activity. However, quinolone alkaloids without the N-methyl group showed a more selective inhibition of NFAT activity.

KW - Evodia rutaecarpa

KW - Nuclear factor activated T cell

KW - Nuclear factor-κB

KW - Quinolone alkaloid

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Quinolone alkaloids with inhibitory activity against nuclear factor of activated T cells from the fruits of Evodia rutaecarpa

Abstract

Keywords

ASJC Scopus subject areas

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