Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires

Xiaoping Hopkins; Waqas Amin Gill; Rosemarie Kringel; Guankui Wang; Jamie Hass; Suresh Acharya; Jungrae Park; In Tak Jeon; Boo Hyun An; Ji Sung Lee; Jong Eun Ryu; Rod Hill; David McIlroy; Young Keun Kim; Daniel S. Choi

doi:10.1088/1361-6528/28/3/03LT01

Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires

Xiaoping Hopkins, Waqas Amin Gill, Rosemarie Kringel, Guankui Wang, Jamie Hass, Suresh Acharya, Jungrae Park, In Tak Jeon, Boo Hyun An, Ji Sung Lee, Jong Eun Ryu, Rod Hill, David McIlroy, Young Keun Kim, Daniel S. Choi

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

We present a novel method of radio frequency (RF)-mediated thermotherapy in tumors by remotely heating nickel (Ni)-gold (Au) core-shell nanowires (CSNWs). Ectopic pancreatic tumors were developed in nude mice to evaluate the thermotherapeutic effects on tumor progression. Tumor ablation was produced by RF-mediated thermotherapy via activation of the paramagnetic properties of the Ni-Au CSNWs. Histopathology demonstrated that heat generated by RF irradiation caused significant cellular death with pyknotic nuclei and nuclear fragmentation dispersed throughout the tumors. These preliminary results suggest that thermotherapy ablation induced via RF activation of nanowires provides a potential alternative therapy for cancer treatment.

Original language	English
Article number	03LT01
Journal	Nanotechnology
Volume	28
Issue number	3
DOIs	https://doi.org/10.1088/1361-6528/28/3/03LT01
Publication status	Published - 2017 Jan 20

Keywords

RF radiation
RF-mediated thermotherapy
cancer
magnetic core-shell nanowire

ASJC Scopus subject areas

Bioengineering
Chemistry(all)
Materials Science(all)
Mechanics of Materials
Mechanical Engineering
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1088/1361-6528/28/3/03LT01

Cite this

Hopkins, X., Gill, W. A., Kringel, R., Wang, G., Hass, J., Acharya, S., Park, J., Jeon, I. T., An, B. H., Lee, J. S., Ryu, J. E., Hill, R., McIlroy, D., Kim, Y. K., & Choi, D. S. (2017). Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires. Nanotechnology, 28(3), [03LT01]. https://doi.org/10.1088/1361-6528/28/3/03LT01

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title = "Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires",

abstract = "We present a novel method of radio frequency (RF)-mediated thermotherapy in tumors by remotely heating nickel (Ni)-gold (Au) core-shell nanowires (CSNWs). Ectopic pancreatic tumors were developed in nude mice to evaluate the thermotherapeutic effects on tumor progression. Tumor ablation was produced by RF-mediated thermotherapy via activation of the paramagnetic properties of the Ni-Au CSNWs. Histopathology demonstrated that heat generated by RF irradiation caused significant cellular death with pyknotic nuclei and nuclear fragmentation dispersed throughout the tumors. These preliminary results suggest that thermotherapy ablation induced via RF activation of nanowires provides a potential alternative therapy for cancer treatment.",

keywords = "RF radiation, RF-mediated thermotherapy, cancer, magnetic core-shell nanowire",

author = "Xiaoping Hopkins and Gill, {Waqas Amin} and Rosemarie Kringel and Guankui Wang and Jamie Hass and Suresh Acharya and Jungrae Park and Jeon, {In Tak} and An, {Boo Hyun} and Lee, {Ji Sung} and Ryu, {Jong Eun} and Rod Hill and David McIlroy and Kim, {Young Keun} and Choi, {Daniel S.}",

note = "Funding Information: D S Choi acknowledges support for this work by the Masdar Institute New Faculty Start-up Funds. Y K Kim acknowledges support by the National Research Foundation of Korea (2014M3A7B4052193, 2015R1A2A1A15053002). The authors are thankful to Ms Audrey Harris and Mr Brad Williams in the University of Idaho Laboratory Animal Research Facility for valuable advice on in vivo experiments. Y K Kim is grateful to Ms H W Seo for supplying additional batches of nanowires. D S Choi is also grateful to Dr Barbara Powers at the Diagnostic Laboratory of Colorado State University for help with histological studies. Publisher Copyright: {\textcopyright} 2016 IOP Publishing Ltd. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

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doi = "10.1088/1361-6528/28/3/03LT01",

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AU - Wang, Guankui

AU - Hass, Jamie

AU - Acharya, Suresh

AU - Park, Jungrae

AU - Jeon, In Tak

AU - An, Boo Hyun

AU - Lee, Ji Sung

AU - Ryu, Jong Eun

AU - Hill, Rod

AU - McIlroy, David

AU - Kim, Young Keun

AU - Choi, Daniel S.

N1 - Funding Information: D S Choi acknowledges support for this work by the Masdar Institute New Faculty Start-up Funds. Y K Kim acknowledges support by the National Research Foundation of Korea (2014M3A7B4052193, 2015R1A2A1A15053002). The authors are thankful to Ms Audrey Harris and Mr Brad Williams in the University of Idaho Laboratory Animal Research Facility for valuable advice on in vivo experiments. Y K Kim is grateful to Ms H W Seo for supplying additional batches of nanowires. D S Choi is also grateful to Dr Barbara Powers at the Diagnostic Laboratory of Colorado State University for help with histological studies. Publisher Copyright: © 2016 IOP Publishing Ltd. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2017/1/20

Y1 - 2017/1/20

N2 - We present a novel method of radio frequency (RF)-mediated thermotherapy in tumors by remotely heating nickel (Ni)-gold (Au) core-shell nanowires (CSNWs). Ectopic pancreatic tumors were developed in nude mice to evaluate the thermotherapeutic effects on tumor progression. Tumor ablation was produced by RF-mediated thermotherapy via activation of the paramagnetic properties of the Ni-Au CSNWs. Histopathology demonstrated that heat generated by RF irradiation caused significant cellular death with pyknotic nuclei and nuclear fragmentation dispersed throughout the tumors. These preliminary results suggest that thermotherapy ablation induced via RF activation of nanowires provides a potential alternative therapy for cancer treatment.

AB - We present a novel method of radio frequency (RF)-mediated thermotherapy in tumors by remotely heating nickel (Ni)-gold (Au) core-shell nanowires (CSNWs). Ectopic pancreatic tumors were developed in nude mice to evaluate the thermotherapeutic effects on tumor progression. Tumor ablation was produced by RF-mediated thermotherapy via activation of the paramagnetic properties of the Ni-Au CSNWs. Histopathology demonstrated that heat generated by RF irradiation caused significant cellular death with pyknotic nuclei and nuclear fragmentation dispersed throughout the tumors. These preliminary results suggest that thermotherapy ablation induced via RF activation of nanowires provides a potential alternative therapy for cancer treatment.

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KW - RF-mediated thermotherapy

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KW - magnetic core-shell nanowire

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Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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