Radionuclide-embedded gold nanoparticles for enhanced dendritic cell-based cancer immunotherapy, sensitive and quantitative tracking of dendritic cells with PET and cerenkov luminescence

Sang Bong Lee, Su Bi Ahn, Sang Woo Lee, Shin Young Jeong, Yoon Ghilsuk, Byeong Cheol Ahn, Eun Mi Kim, Hwan Jeong Jeong, Jaetae Lee, Dong Kwon Lim, Yong Hyun Jeon

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

Radionuclide-embedded gold nanoparticles (RIe-AuNPs) were developed as a highly sensitive and stable nuclear and optical imaging agent for efficient dendritic cell (DC)-based immunotherapy and sensitive tracking of DC-migration to lymph nodes. The RIe-AuNPs were synthesized via simple and straightforward DNA-based radiolabeling chemistry and additional Au shell formation strategies, leading to high radiosensitivity and excellent in vivo stability. The RIe-AuNPs exert no adverse effects on the biological functions of DCs, and labeled DCs show strong antitumor immunity for lung cancer. Furthermore, the high radiosensitivity of the RIe-AuNPs allows for sensitive and long-term monitoring of DC migration to draining lymph nodes. The developed Cerenkov radiation-based optical imaging approach provides quantitative and sensitive results comparable with that of positron emission tomography imaging. These results highlight the strong potential of the RIe-AuNPs as a highly sensitive and stable nuclear and optical imaging platform for future bioimaging application such as cell tracking and tumor imaging.

Original languageEnglish
Article numbere281
Pages (from-to)1-10
Number of pages10
JournalNPG Asia Materials
Volume8
Issue number6
DOIs
Publication statusPublished - 2016

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF-2013R1A1A1061387), KU-KIST research fund, a National Research Foundation of Korea (NRF) grant funded by the Korean Government (MEST, 2009-0078234), the National Nuclear R&D Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science and Technology (No. 2012M2A2A7014020), a grant from the Korea Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A111345), the Medical Cluster R&D Support Project of Daegu Gyeong-buk Medical Innovation Foundation, and a National Research Foundation of Korea (NRF) Grant funded by the Korean Government (MSIP) (2014R1A1A1003323). This work was also supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2009-0078222, 2009-0078234), a grant of the Korea Health technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (Grant No. HI16C1501), National Nuclear R&D Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (No. 2012M2A2A7014020), a grant from the Medical Cluster R&D Support Project through the Daegu-Gyengbuk Medical Innovation Foundation (DGMIF), funded by the Ministry of Health & Welfare (Grant No. HT13C0002), BK21 PlusKNU Biomedical Convergence Program, Department of Biomedical Science, Kyungpook National University, National Research Foundation of Korea (NRF) grant funded by the Korea Government (MSIP) (No. 2014R1A1A1003323), a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare (Grant No. HI15C0001), Radiation Technology R&D program through the National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning (NRF-2012M2A2A7013480), and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. NRF-2015M2A2A7A01045177).

Publisher Copyright:
© The Author(s) 2016.

ASJC Scopus subject areas

  • Modelling and Simulation
  • General Materials Science
  • Condensed Matter Physics

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