TY - JOUR
T1 - Radiosurgery for brain metastasis from advanced gastric cancer
AU - Han, Jung Ho
AU - Kim, Dong Gyu
AU - Chung, Hyun Tai
AU - Kim, Chae Yong
AU - Park, Chul Kee
AU - Chung, Young Seob
AU - Paek, Sun Ha
AU - Yoo, Moon Won
AU - Kim, Baek Hui
AU - Jung, Hee Won
PY - 2010/4
Y1 - 2010/4
N2 - Purpose We retrospectively evaluated the survival of patients with brain metastases from advanced gastric cancer (AGC) after radiosurgery (RS). Methods Between 1998 and 2007, a total of 11 patients (median age, 61 years; range, 36-70) were diagnosed with brain metastasis from AGC and treated with RS. Each of five (46%) patients had two brain metastases. The median volume of the 16 lesions was 2.9 cm3 (range, 0.1-33.8). The median marginal dose prescribed was 20 Gy (range, 10-25) at the 50% isodose line. RS was the primary treatment for brain metastases in six patients. Results As of February 28, 2008, eight (73%) patients had died, and three (27%) were living with stable disease. The median survival time was 17.0±3.9 months (95% CI, 9.4-24.6). The median progression-free survival time was 9.0± 2.5 months (95% CI, 4.2-13.8). Patients who did not undergo WBRT died within 8 months, and the other six patients treated with WBRT at various time intervals from the diagnosis of brain metastases survived, with a median survival time of 19.0±3.4 months (95% CI, 12.4-25.6). Conclusions Radiosurgery seems to be a good alternative to surgical resection for patients with brain metastases from AGC, when performed in conjunction with WBRT.
AB - Purpose We retrospectively evaluated the survival of patients with brain metastases from advanced gastric cancer (AGC) after radiosurgery (RS). Methods Between 1998 and 2007, a total of 11 patients (median age, 61 years; range, 36-70) were diagnosed with brain metastasis from AGC and treated with RS. Each of five (46%) patients had two brain metastases. The median volume of the 16 lesions was 2.9 cm3 (range, 0.1-33.8). The median marginal dose prescribed was 20 Gy (range, 10-25) at the 50% isodose line. RS was the primary treatment for brain metastases in six patients. Results As of February 28, 2008, eight (73%) patients had died, and three (27%) were living with stable disease. The median survival time was 17.0±3.9 months (95% CI, 9.4-24.6). The median progression-free survival time was 9.0± 2.5 months (95% CI, 4.2-13.8). Patients who did not undergo WBRT died within 8 months, and the other six patients treated with WBRT at various time intervals from the diagnosis of brain metastases survived, with a median survival time of 19.0±3.4 months (95% CI, 12.4-25.6). Conclusions Radiosurgery seems to be a good alternative to surgical resection for patients with brain metastases from AGC, when performed in conjunction with WBRT.
KW - Advanced gastric carcinoma
KW - Brain metastasis
KW - Gamma Knife radiosurgery
KW - Whole-brain radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=77953025998&partnerID=8YFLogxK
U2 - 10.1007/s00701-009-0554-4
DO - 10.1007/s00701-009-0554-4
M3 - Article
C2 - 19907917
AN - SCOPUS:77953025998
SN - 0001-6268
VL - 152
SP - 605
EP - 610
JO - Acta Neurochirurgica
JF - Acta Neurochirurgica
IS - 4
ER -
