RanBPM protein acts as a negative regulator of BLT2 receptor to attenuate BLT2-mediated cell motility

Jun Dong Wei; Joo Young Kim; Ae Kyoung Kim; Sung Key Jang; Jae Hong Kim

doi:10.1074/jbc.M113.470260

RanBPM protein acts as a negative regulator of BLT2 receptor to attenuate BLT2-mediated cell motility

Jun Dong Wei, Joo Young Kim, Ae Kyoung Kim, Sung Key Jang, Jae Hong Kim

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Background: The regulatory mechanism of BLT2 is largely unknown. Results: RanBPM interacts with BLT2 and inhibits BLT2-induced ROS generation and chemotaxis. Conclusion: Our findings suggest that RanBPM acts as a negative regulator of BLT2. Significance: Identification of regulators would provide better understanding of BLT2 signaling and potentially various BLT2- associated inflammatory pathogenesis.

Original language	English
Pages (from-to)	26753-26763
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	37
DOIs	https://doi.org/10.1074/jbc.M113.470260
Publication status	Published - 2013 Sept 13

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "RanBPM protein acts as a negative regulator of BLT2 receptor to attenuate BLT2-mediated cell motility",

abstract = "Background: The regulatory mechanism of BLT2 is largely unknown. Results: RanBPM interacts with BLT2 and inhibits BLT2-induced ROS generation and chemotaxis. Conclusion: Our findings suggest that RanBPM acts as a negative regulator of BLT2. Significance: Identification of regulators would provide better understanding of BLT2 signaling and potentially various BLT2- associated inflammatory pathogenesis.",

author = "Wei, {Jun Dong} and Kim, {Joo Young} and Kim, {Ae Kyoung} and Jang, {Sung Key} and Kim, {Jae Hong}",

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AU - Wei, Jun Dong

AU - Kim, Joo Young

AU - Kim, Ae Kyoung

AU - Jang, Sung Key

AU - Kim, Jae Hong

PY - 2013/9/13

Y1 - 2013/9/13

N2 - Background: The regulatory mechanism of BLT2 is largely unknown. Results: RanBPM interacts with BLT2 and inhibits BLT2-induced ROS generation and chemotaxis. Conclusion: Our findings suggest that RanBPM acts as a negative regulator of BLT2. Significance: Identification of regulators would provide better understanding of BLT2 signaling and potentially various BLT2- associated inflammatory pathogenesis.

AB - Background: The regulatory mechanism of BLT2 is largely unknown. Results: RanBPM interacts with BLT2 and inhibits BLT2-induced ROS generation and chemotaxis. Conclusion: Our findings suggest that RanBPM acts as a negative regulator of BLT2. Significance: Identification of regulators would provide better understanding of BLT2 signaling and potentially various BLT2- associated inflammatory pathogenesis.

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M3 - Article

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AN - SCOPUS:84884189258

SN - 0021-9258

VL - 288

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EP - 26763

JO - Journal of Biological Chemistry

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RanBPM protein acts as a negative regulator of BLT2 receptor to attenuate BLT2-mediated cell motility

Abstract

ASJC Scopus subject areas

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