RanBPM protein acts as a negative regulator of BLT2 receptor to attenuate BLT2-mediated cell motility

Jun Dong Wei; Joo Young Kim; Ae Kyoung Kim; Sung Key Jang; Jae Hong Kim

doi:10.1074/jbc.M113.470260

RanBPM protein acts as a negative regulator of BLT2 receptor to attenuate BLT2-mediated cell motility

Jun Dong Wei
, Joo Young Kim
, Ae Kyoung Kim
, Sung Key Jang
, Jae Hong Kim^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Background: The regulatory mechanism of BLT2 is largely unknown. Results: RanBPM interacts with BLT2 and inhibits BLT2-induced ROS generation and chemotaxis. Conclusion: Our findings suggest that RanBPM acts as a negative regulator of BLT2. Significance: Identification of regulators would provide better understanding of BLT2 signaling and potentially various BLT2- associated inflammatory pathogenesis.

Original language	English
Pages (from-to)	26753-26763
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	37
DOIs	https://doi.org/10.1074/jbc.M113.470260
Publication status	Published - 2013 Sept 13

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.470260

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title = "RanBPM protein acts as a negative regulator of BLT2 receptor to attenuate BLT2-mediated cell motility",

abstract = "Background: The regulatory mechanism of BLT2 is largely unknown. Results: RanBPM interacts with BLT2 and inhibits BLT2-induced ROS generation and chemotaxis. Conclusion: Our findings suggest that RanBPM acts as a negative regulator of BLT2. Significance: Identification of regulators would provide better understanding of BLT2 signaling and potentially various BLT2- associated inflammatory pathogenesis.",

author = "Wei, \{Jun Dong\} and Kim, \{Joo Young\} and Kim, \{Ae Kyoung\} and Jang, \{Sung Key\} and Kim, \{Jae Hong\}",

year = "2013",

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doi = "10.1074/jbc.M113.470260",

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journal = "Journal of Biological Chemistry",

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T1 - RanBPM protein acts as a negative regulator of BLT2 receptor to attenuate BLT2-mediated cell motility

AU - Wei, Jun Dong

AU - Kim, Joo Young

AU - Kim, Ae Kyoung

AU - Jang, Sung Key

AU - Kim, Jae Hong

PY - 2013/9/13

Y1 - 2013/9/13

N2 - Background: The regulatory mechanism of BLT2 is largely unknown. Results: RanBPM interacts with BLT2 and inhibits BLT2-induced ROS generation and chemotaxis. Conclusion: Our findings suggest that RanBPM acts as a negative regulator of BLT2. Significance: Identification of regulators would provide better understanding of BLT2 signaling and potentially various BLT2- associated inflammatory pathogenesis.

AB - Background: The regulatory mechanism of BLT2 is largely unknown. Results: RanBPM interacts with BLT2 and inhibits BLT2-induced ROS generation and chemotaxis. Conclusion: Our findings suggest that RanBPM acts as a negative regulator of BLT2. Significance: Identification of regulators would provide better understanding of BLT2 signaling and potentially various BLT2- associated inflammatory pathogenesis.

UR - https://www.scopus.com/pages/publications/84884189258

U2 - 10.1074/jbc.M113.470260

DO - 10.1074/jbc.M113.470260

M3 - Article

C2 - 23928309

AN - SCOPUS:84884189258

SN - 0021-9258

VL - 288

SP - 26753

EP - 26763

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 37

ER -

RanBPM protein acts as a negative regulator of BLT2 receptor to attenuate BLT2-mediated cell motility

Abstract

ASJC Scopus subject areas

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