Rapid chemical shift encoding with single-acquisition single-slab 3D GRASE

Hahnsung Kim, Dong Hyun Kim, Chul Ho Sohn, Jaeseok Park

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Purpose: To investigate the feasibility of chemical shift encoded, single-slab 3D GRASE for rapid fat–water separation within a single acquisition. Methods: The proposed method incorporates signal-to-noise-ratio-optimal chemical shift encoding into single-slab 3D GRASE with variable flip angles. Chemical shift induced phase information was encoded in succession to different positions in k-space by inserting phase encoding blips between adjacent lobes of the oscillating readout gradients. To enhance imaging efficiency, signal prescription-based variable flip angles were used in the long refocusing pulse train. After echo-independent phase correction, missing signals in k-echo space were interpolated using convolution kernels that span over all echoes. Fat–water separation in a single acquisition was performed using both multi-echo fast spin echo and GRASE as compared to conventional multiacquisition fast spin echo with echo shifts. Results: The proposed single-slab 3D GRASE shows superior performance in accurately delineating cartilage structures compared to its counterpart, multi-echo 3D fast spin echo. Compared with multiacquisition fast spin echo with three echo shifts (63 min), the proposed method substantially speeds up imaging time (7 min), and achieves 0.6 mm isotropic resolution in knee imaging with reduced artifacts and noise. Conclusion: We successfully demonstrated the feasibility of rapid chemical shift encoding and separation using the proposed, single-acquisition single-slab 3D GRASE for high resolution isotropic imaging within clinically acceptable time. Magn Reson Med 78:1852–1861, 2017.

Original languageEnglish
Pages (from-to)1852-1861
Number of pages10
JournalMagnetic Resonance in Medicine
Issue number5
Publication statusPublished - 2017 Nov

Bibliographical note

Funding Information:
1Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea. 2Department of Electrical and Electronic Engineering, Yonsei University, Seoul, Republic of Korea. 3Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea. Grant sponsor: Brain Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (2016M3C7A1913844). *Correspondence to: Jaeseok Park, Ph.D., Department of Biomedical Engineering, Sungkyunkwan University, 2066, Seobu-Ro, Jangan-Gu, Suwon, Republic of Korea. E-mail: jaeseokpark.biel@gmail.com Received 29 July 2016; revised 8 December 2016; accepted 8 December 2016 DOI 10.1002/mrm.26595 Published online 11 January 2017 in Wiley Online Library (wileyonlinelibrary. com).

Publisher Copyright:
© 2017 International Society for Magnetic Resonance in Medicine


  • 3D
  • fat–water separation
  • gradient- and spin-echo
  • magnetic resonance imaging
  • variable flip angle

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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