Abstract
The assessment of hemostasis and fibrinolysis is essential in emergency settings to make timely medical decisions. While conventional thromboelastography (TEG) analyzers provide comprehensive information on blood clotting, their long test times are often unsuitable for emergency patients. In this study, we propose an innovative method of microfluidic thromboelastography (μ-TEG) that rapidly measures the viscoelastic properties of blood coagulation in oscillating flow through circular tubes. Our μ-TEG system moves a blood sample back and forth through a circular tube subjected to sinusoidal pressure, generating shear rates ranging from 1.2 to 20 s−1, higher than those of conventional TEGs. The movements are monitored by a pressure sensor and converted to a conventional TEG. Key parameters such as MA and Ly30 can be acquired within 10–12 min for normal samples. Our study showed that the increased shear rate in the μ-TEG system alters the coagulation mechanism, resulting in increased coagulation strength and rapid fibrinolysis. Despite the short test time, the μ-TEG showed good agreement with the TEG5000. The rapid measurement of μ-TEG makes it a useful tool for analyzing hemostasis and fibrinolysis in emergency and operating rooms.
| Original language | English |
|---|---|
| Article number | 133873 |
| Journal | Sensors and Actuators B: Chemical |
| Volume | 390 |
| DOIs | |
| Publication status | Published - 2023 Sept 1 |
Bibliographical note
Publisher Copyright:© 2023 The Authors
Keywords
- Coagulation
- Fibrinolysis
- Microfluidic
- Shear rates
- Thromboelastography
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Instrumentation
- Condensed Matter Physics
- Surfaces, Coatings and Films
- Metals and Alloys
- Electrical and Electronic Engineering
- Materials Chemistry