Ras promotes transforming growth factor-β(TGF-β)-induced epithelial-mesenchymal transition via a leukotriene B4 receptor-2-linked cascade in mammary epithelial cells

Hyunju Kim; Jung A. Choi; Jae Hong Kim

doi:10.1074/jbc.M114.556126

Ras promotes transforming growth factor-β(TGF-β)-induced epithelial-mesenchymal transition via a leukotriene B₄ receptor-2-linked cascade in mammary epithelial cells

Hyunju Kim, Jung A. Choi, Jae Hong Kim

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Background: The mechanism by which oncogenic Ras contributes to epithelial-mesenchymal transition (EMT) is not clearly defined. Results: The "BLT2-ROS-NF-κB"-linked cascade lies downstream of Ras and promotes EMT. Conclusion: Activation of leukotriene B₄ receptor-2 (BLT2)-linked pathway contributes to EMT in mammary epithelial cells. Significance: These findings suggest that BLT2 is a novel regulator of EMT in mammary epithelial cells.

Original language	English
Pages (from-to)	22151-22160
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	289
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M114.556126
Publication status	Published - 2014 Aug 8

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Ras promotes transforming growth factor-β(TGF-β)-induced epithelial-mesenchymal transition via a leukotriene B4 receptor-2-linked cascade in mammary epithelial cells",

abstract = "Background: The mechanism by which oncogenic Ras contributes to epithelial-mesenchymal transition (EMT) is not clearly defined. Results: The {"}BLT2-ROS-NF-κB{"}-linked cascade lies downstream of Ras and promotes EMT. Conclusion: Activation of leukotriene B4 receptor-2 (BLT2)-linked pathway contributes to EMT in mammary epithelial cells. Significance: These findings suggest that BLT2 is a novel regulator of EMT in mammary epithelial cells.",

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AU - Choi, Jung A.

AU - Kim, Jae Hong

PY - 2014/8/8

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AB - Background: The mechanism by which oncogenic Ras contributes to epithelial-mesenchymal transition (EMT) is not clearly defined. Results: The "BLT2-ROS-NF-κB"-linked cascade lies downstream of Ras and promotes EMT. Conclusion: Activation of leukotriene B4 receptor-2 (BLT2)-linked pathway contributes to EMT in mammary epithelial cells. Significance: These findings suggest that BLT2 is a novel regulator of EMT in mammary epithelial cells.

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Ras promotes transforming growth factor-β(TGF-β)-induced epithelial-mesenchymal transition via a leukotriene B₄ receptor-2-linked cascade in mammary epithelial cells

Abstract

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