Ras promotes transforming growth factor-β(TGF-β)-induced epithelial-mesenchymal transition via a leukotriene B4 receptor-2-linked cascade in mammary epithelial cells

Hyunju Kim, Jung A. Choi, Jae Hong Kim

    Research output: Contribution to journalArticlepeer-review

    42 Citations (Scopus)

    Abstract

    Background: The mechanism by which oncogenic Ras contributes to epithelial-mesenchymal transition (EMT) is not clearly defined. Results: The "BLT2-ROS-NF-κB"-linked cascade lies downstream of Ras and promotes EMT. Conclusion: Activation of leukotriene B4 receptor-2 (BLT2)-linked pathway contributes to EMT in mammary epithelial cells. Significance: These findings suggest that BLT2 is a novel regulator of EMT in mammary epithelial cells.

    Original languageEnglish
    Pages (from-to)22151-22160
    Number of pages10
    JournalJournal of Biological Chemistry
    Volume289
    Issue number32
    DOIs
    Publication statusPublished - 2014 Aug 8

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Cell Biology

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