Abstract
Background: The mechanism by which oncogenic Ras contributes to epithelial-mesenchymal transition (EMT) is not clearly defined. Results: The "BLT2-ROS-NF-κB"-linked cascade lies downstream of Ras and promotes EMT. Conclusion: Activation of leukotriene B4 receptor-2 (BLT2)-linked pathway contributes to EMT in mammary epithelial cells. Significance: These findings suggest that BLT2 is a novel regulator of EMT in mammary epithelial cells.
Original language | English |
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Pages (from-to) | 22151-22160 |
Number of pages | 10 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 32 |
DOIs | |
Publication status | Published - 2014 Aug 8 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology