Rational design of biotin-disulfide-coumarin conjugates: a cancer targeted thiol probe and bioimaging

Danbi Jung; Sukhendu Maiti; Jae Hong Lee; Joung Hae Lee; Jong Seung Kim

doi:10.1039/c3cc49790a

Rational design of biotin-disulfide-coumarin conjugates: a cancer targeted thiol probe and bioimaging

Danbi Jung, Sukhendu Maiti, Jae Hong Lee, Joung Hae Lee, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

Biotin-disulfide-coumarin conjugates are designed and synthesized as novel fluorescent sensors for cancer targeted intracellular thiol imaging in living organisms. In vitro experiments disclose that probe 6 is preferentially taken up by biotin receptor-positive A549 tumor cells through receptor mediated endocytosis.

Original language	English
Pages (from-to)	3044-3047
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	23
DOIs	https://doi.org/10.1039/c3cc49790a
Publication status	Published - 2014 Feb 20

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c3cc49790a

Cite this

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abstract = "Biotin-disulfide-coumarin conjugates are designed and synthesized as novel fluorescent sensors for cancer targeted intracellular thiol imaging in living organisms. In vitro experiments disclose that probe 6 is preferentially taken up by biotin receptor-positive A549 tumor cells through receptor mediated endocytosis.",

author = "Danbi Jung and Sukhendu Maiti and Lee, {Jae Hong} and Lee, {Joung Hae} and Kim, {Jong Seung}",

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AU - Lee, Joung Hae

AU - Kim, Jong Seung

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Rational design of biotin-disulfide-coumarin conjugates: a cancer targeted thiol probe and bioimaging

Abstract

ASJC Scopus subject areas

UN SDGs

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