Rational design of biotin-disulfide-coumarin conjugates: a cancer targeted thiol probe and bioimaging

Danbi Jung, Sukhendu Maiti, Jae Hong Lee, Joung Hae Lee, Jong Seung Kim

    Research output: Contribution to journalArticlepeer-review

    76 Citations (Scopus)

    Abstract

    Biotin-disulfide-coumarin conjugates are designed and synthesized as novel fluorescent sensors for cancer targeted intracellular thiol imaging in living organisms. In vitro experiments disclose that probe 6 is preferentially taken up by biotin receptor-positive A549 tumor cells through receptor mediated endocytosis.

    Original languageEnglish
    Pages (from-to)3044-3047
    Number of pages4
    JournalChemical Communications
    Volume50
    Issue number23
    DOIs
    Publication statusPublished - 2014 Feb 20

    ASJC Scopus subject areas

    • Catalysis
    • Electronic, Optical and Magnetic Materials
    • Ceramics and Composites
    • General Chemistry
    • Surfaces, Coatings and Films
    • Metals and Alloys
    • Materials Chemistry

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