TY - JOUR
T1 - Re-evaluation of the effects of norepinephrine on the single-unit activity of paraventricular neurosecretory neurons
AU - Kim, Yang I.
AU - Dudley, Carol A.
AU - Moss, Robert L.
N1 - Funding Information:
The authors would like to thank Angela Sherrin for excellent technical assistance, Valerie C. Ditta for aid in manuscript preparation, and J.T. Gean for programming acquisition and analysis software. This research was supported by NIH Grants HD09988-II and HD09988-V awarded to R.L.M.
PY - 1989/2/13
Y1 - 1989/2/13
N2 - Electrical stimulation of the A1 noradrenergic region elicited predominantly an excitatory orthodromic response from paraventricular neurosecretory neurons recorded in urethane-anesthetized male rats. In a majority of cases, locally applied norepinephrine (NE) as well as A1 region stimulation excited paraventricular neurosecretory neurons. However, in some neurons including a subpopulation of putative vasopressin neurons, iontophoresed NE was inhibitory. Both excitatory and inhibitory effects of NE were selectively blocked by the α-antagonist, phentolamine, but not by the β-antagonist, timolol. In general, the results support the notion that the A1 noradrenergic input to paraventricular neurosecretory neurons is excitatory. Nevertheless, the results do not exclude the possibility that NE exerts a specific, α-receptormediated, inhibitory effect on a subpopulation of paraventricular neurons.
AB - Electrical stimulation of the A1 noradrenergic region elicited predominantly an excitatory orthodromic response from paraventricular neurosecretory neurons recorded in urethane-anesthetized male rats. In a majority of cases, locally applied norepinephrine (NE) as well as A1 region stimulation excited paraventricular neurosecretory neurons. However, in some neurons including a subpopulation of putative vasopressin neurons, iontophoresed NE was inhibitory. Both excitatory and inhibitory effects of NE were selectively blocked by the α-antagonist, phentolamine, but not by the β-antagonist, timolol. In general, the results support the notion that the A1 noradrenergic input to paraventricular neurosecretory neurons is excitatory. Nevertheless, the results do not exclude the possibility that NE exerts a specific, α-receptormediated, inhibitory effect on a subpopulation of paraventricular neurons.
KW - A1 noradrenergic region
KW - Iontophoresis
KW - Norepinephrine
KW - Paraventricular nucleus
KW - Phentolamine
KW - Putative vasopressin neuron
KW - Timolol
UR - http://www.scopus.com/inward/record.url?scp=0024495448&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(89)90147-X
DO - 10.1016/0304-3940(89)90147-X
M3 - Article
C2 - 2918991
AN - SCOPUS:0024495448
SN - 0304-3940
VL - 97
SP - 103
EP - 110
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1-2
ER -