As a well-known toxic air pollutant, SO 2 and its derivatives can cause great harm to the human body, including respiratory responses, allergic reactions, cancer, neurological disorders and cardiovascular diseases. On the other hand, SO 2 can be endogenously generated in mammals and serves as a gaseous signaling molecule. Evidences show that SO 2 and its derivatives play crucial roles in modulating a wide range of physiological processes, including vasodilatation, antihypertension, regulation of cardiovascular function and intracellular redox status. The molecular mechanisms dictating the biological formation of SO 2 and its role in many biological processes remain largely unclear. Reaction-based fluorescent probes offer powerful means to monitor the physiological actions of SO 2 derivatives in their native environments with minimal perturbation to the living systems. This review shows up-to-date research trends on reaction-based fluorescent probes for SO 2 derivatives. The design principles and chemical structures of the probes and their biological applications are highlighted.
Bibliographical noteFunding Information:
This work was financially supported by National Natural Science Foundation of China (No.: 21572147 , 21472131 and 21877082 ).
© 2019 Elsevier B.V.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Inorganic Chemistry
- Materials Chemistry