Reaction-based fluorescent probes for SO 2 derivatives and their biological applications

Kun Li, Ling Ling Li, Qian Zhou, Kang Kang Yu, Jong Seung Kim, Xiao Qi Yu

Research output: Contribution to journalReview articlepeer-review

124 Citations (Scopus)


As a well-known toxic air pollutant, SO 2 and its derivatives can cause great harm to the human body, including respiratory responses, allergic reactions, cancer, neurological disorders and cardiovascular diseases. On the other hand, SO 2 can be endogenously generated in mammals and serves as a gaseous signaling molecule. Evidences show that SO 2 and its derivatives play crucial roles in modulating a wide range of physiological processes, including vasodilatation, antihypertension, regulation of cardiovascular function and intracellular redox status. The molecular mechanisms dictating the biological formation of SO 2 and its role in many biological processes remain largely unclear. Reaction-based fluorescent probes offer powerful means to monitor the physiological actions of SO 2 derivatives in their native environments with minimal perturbation to the living systems. This review shows up-to-date research trends on reaction-based fluorescent probes for SO 2 derivatives. The design principles and chemical structures of the probes and their biological applications are highlighted.

Original languageEnglish
Pages (from-to)310-333
Number of pages24
JournalCoordination Chemistry Reviews
Publication statusPublished - 2019 Jun 1

Bibliographical note

Funding Information:
This work was financially supported by National Natural Science Foundation of China (No.: 21572147 , 21472131 and 21877082 ).

Publisher Copyright:
© 2019 Elsevier B.V.

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry


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