Abstract
Salubrinal is a specific eIF2α phosphatase inhibitor that inhibits ER stress-mediated apoptosis. However, maintaining hyper-phosphorylated eIF2α state with high doses of salubrinal treatment promotes apoptosis in some cancer cells. In this report, we found that salubrinal induced apoptosis of EBV-transformed B cells. Notably, salubrinal induced ROS generation and p38 MPAK activation, which then induced expression of FasL. Moreover, salubrinal subsequently led to activation of caspases, calcium redistribution, Bax translocation, cytochrome c release, and apoptosis. These findings suggest that salubrinal may be a novel therapeutic approach for EBV-associated malignant diseases.
Original language | English |
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Pages (from-to) | 235-248 |
Number of pages | 14 |
Journal | Cancer letters |
Volume | 313 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2011 Dec 27 |
Externally published | Yes |
Keywords
- Apoptosis
- B cell
- Bax
- Calcium
- EBV
- P38 MAPK
- ROS
- Salubrinal
ASJC Scopus subject areas
- Oncology
- Cancer Research