Reactive oxygen species, thiols and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics

Jun Li, Yi Zhang, Pengzhan Wang, Le Yu, Jusung An, Ganzhen Deng, Yao Sun, Jong Seung Kim

Research output: Contribution to journalReview articlepeer-review

48 Citations (Scopus)

Abstract

Reactive oxygen species (ROS), thiols and enzymes are regarded as important biomarkers in the physiological process. The abnormal levels of the above species are associated with many diseases, developing a fluorescence detection method for biomarkers is of great significance for diseases early diagnosis and therapy. Compared with traditional fluorescent dyes, aggregation-induced emission (AIE) based fluorescent emitters display excellent photostability with minimum aggregation caused quenching (ACQ) effect. Thus, the biomarker-activable AIEgens have attracted much attentions in biomedical research. In addition, many AIE emitters not only act as fluorescent dyes, but serve as promising theranostic agents. The AIE based image-guided multifunctional theranostics under the activation of biomarkers are vital to the precise biomedicine. This view focuses on the recent development of ROS, thiols, and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics.

Original languageEnglish
Article number213559
JournalCoordination Chemistry Reviews
Volume427
DOIs
Publication statusPublished - 2021 Jan 15

Bibliographical note

Funding Information:
This work was supported by grants from National Research Foundation of Korea (CRI project: 2018R1A3B1052702 and 2019M3E5D1A01068998 ,J.S.K.), and NSFC ( 21806048 , 31972744 ), and the Fundamental Research Funds for the Central Universities (No. 2662018QD009), Wuhan Scientific and Technological Projects (2019020701011441), the Research Fund Program of Guangdong Key Laboratory of Radioactive and Rare Resource Utilization (NO. 2019-LRRRU03), Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology (No: OHIC2019K01). The Key Laboratory of Spectroscopy Sensing, Ministry of Agriculture and Rural Affairs, P. R. China (2020ZJUGP003).

Funding Information:
This work was supported by grants from National Research Foundation of Korea (CRI project: 2018R1A3B1052702 and 2019M3E5D1A01068998,J.S.K.), and NSFC (21806048,31972744), and the Fundamental Research Funds for the Central Universities (No. 2662018QD009), Wuhan Scientific and Technological Projects (2019020701011441), the Research Fund Program of Guangdong Key Laboratory of Radioactive and Rare Resource Utilization (NO. 2019-LRRRU03), Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology (No: OHIC2019K01). The Key Laboratory of Spectroscopy Sensing, Ministry of Agriculture and Rural Affairs, P. R. China (2020ZJUGP003).

Publisher Copyright:
© 2020 Elsevier B.V.

Keywords

  • Activable AIEgens
  • Aggregation-induced emission
  • Fluorescence Imaging
  • Small-molecule dye
  • Theranostics

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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