Reactive oxygen species, thiols and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics

Jun Li; Yi Zhang; Pengzhan Wang; Le Yu; Jusung An; Ganzhen Deng; Yao Sun; Jong Seung Kim

doi:10.1016/j.ccr.2020.213559

Reactive oxygen species, thiols and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics

Jun Li, Yi Zhang, Pengzhan Wang, Le Yu, Jusung An, Ganzhen Deng, Yao Sun, Jong Seung Kim

Research output: Contribution to journal › Review article › peer-review

44 Citations (Scopus)

Abstract

Reactive oxygen species (ROS), thiols and enzymes are regarded as important biomarkers in the physiological process. The abnormal levels of the above species are associated with many diseases, developing a fluorescence detection method for biomarkers is of great significance for diseases early diagnosis and therapy. Compared with traditional fluorescent dyes, aggregation-induced emission (AIE) based fluorescent emitters display excellent photostability with minimum aggregation caused quenching (ACQ) effect. Thus, the biomarker-activable AIEgens have attracted much attentions in biomedical research. In addition, many AIE emitters not only act as fluorescent dyes, but serve as promising theranostic agents. The AIE based image-guided multifunctional theranostics under the activation of biomarkers are vital to the precise biomedicine. This view focuses on the recent development of ROS, thiols, and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics.

Original language	English
Article number	213559
Journal	Coordination Chemistry Reviews
Volume	427
DOIs	https://doi.org/10.1016/j.ccr.2020.213559
Publication status	Published - 2021 Jan 15

Bibliographical note

Funding Information:
This work was supported by grants from National Research Foundation of Korea (CRI project: 2018R1A3B1052702 and 2019M3E5D1A01068998 ,J.S.K.), and NSFC ( 21806048 , 31972744 ), and the Fundamental Research Funds for the Central Universities (No. 2662018QD009), Wuhan Scientific and Technological Projects (2019020701011441), the Research Fund Program of Guangdong Key Laboratory of Radioactive and Rare Resource Utilization (NO. 2019-LRRRU03), Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology (No: OHIC2019K01). The Key Laboratory of Spectroscopy Sensing, Ministry of Agriculture and Rural Affairs, P. R. China (2020ZJUGP003).

Funding Information:
This work was supported by grants from National Research Foundation of Korea (CRI project: 2018R1A3B1052702 and 2019M3E5D1A01068998,J.S.K.), and NSFC (21806048,31972744), and the Fundamental Research Funds for the Central Universities (No. 2662018QD009), Wuhan Scientific and Technological Projects (2019020701011441), the Research Fund Program of Guangdong Key Laboratory of Radioactive and Rare Resource Utilization (NO. 2019-LRRRU03), Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology (No: OHIC2019K01). The Key Laboratory of Spectroscopy Sensing, Ministry of Agriculture and Rural Affairs, P. R. China (2020ZJUGP003).

Publisher Copyright:
© 2020 Elsevier B.V.

Keywords

Activable AIEgens
Aggregation-induced emission
Fluorescence Imaging
Small-molecule dye
Theranostics

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

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10.1016/j.ccr.2020.213559

Cite this

@article{3a7012f9c8ce4160b5458faf07a17ba6,

title = "Reactive oxygen species, thiols and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics",

abstract = "Reactive oxygen species (ROS), thiols and enzymes are regarded as important biomarkers in the physiological process. The abnormal levels of the above species are associated with many diseases, developing a fluorescence detection method for biomarkers is of great significance for diseases early diagnosis and therapy. Compared with traditional fluorescent dyes, aggregation-induced emission (AIE) based fluorescent emitters display excellent photostability with minimum aggregation caused quenching (ACQ) effect. Thus, the biomarker-activable AIEgens have attracted much attentions in biomedical research. In addition, many AIE emitters not only act as fluorescent dyes, but serve as promising theranostic agents. The AIE based image-guided multifunctional theranostics under the activation of biomarkers are vital to the precise biomedicine. This view focuses on the recent development of ROS, thiols, and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics.",

keywords = "Activable AIEgens, Aggregation-induced emission, Fluorescence Imaging, Small-molecule dye, Theranostics",

author = "Jun Li and Yi Zhang and Pengzhan Wang and Le Yu and Jusung An and Ganzhen Deng and Yao Sun and {Seung Kim}, Jong",

note = "Funding Information: This work was supported by grants from National Research Foundation of Korea (CRI project: 2018R1A3B1052702 and 2019M3E5D1A01068998 ,J.S.K.), and NSFC ( 21806048 , 31972744 ), and the Fundamental Research Funds for the Central Universities (No. 2662018QD009), Wuhan Scientific and Technological Projects (2019020701011441), the Research Fund Program of Guangdong Key Laboratory of Radioactive and Rare Resource Utilization (NO. 2019-LRRRU03), Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology (No: OHIC2019K01). The Key Laboratory of Spectroscopy Sensing, Ministry of Agriculture and Rural Affairs, P. R. China (2020ZJUGP003). Funding Information: This work was supported by grants from National Research Foundation of Korea (CRI project: 2018R1A3B1052702 and 2019M3E5D1A01068998,J.S.K.), and NSFC (21806048,31972744), and the Fundamental Research Funds for the Central Universities (No. 2662018QD009), Wuhan Scientific and Technological Projects (2019020701011441), the Research Fund Program of Guangdong Key Laboratory of Radioactive and Rare Resource Utilization (NO. 2019-LRRRU03), Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology (No: OHIC2019K01). The Key Laboratory of Spectroscopy Sensing, Ministry of Agriculture and Rural Affairs, P. R. China (2020ZJUGP003). Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2021",

month = jan,

day = "15",

doi = "10.1016/j.ccr.2020.213559",

language = "English",

volume = "427",

journal = "Coordination Chemistry Reviews",

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T1 - Reactive oxygen species, thiols and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics

AU - Li, Jun

AU - Zhang, Yi

AU - Wang, Pengzhan

AU - Yu, Le

AU - An, Jusung

AU - Deng, Ganzhen

AU - Sun, Yao

AU - Seung Kim, Jong

N1 - Funding Information: This work was supported by grants from National Research Foundation of Korea (CRI project: 2018R1A3B1052702 and 2019M3E5D1A01068998 ,J.S.K.), and NSFC ( 21806048 , 31972744 ), and the Fundamental Research Funds for the Central Universities (No. 2662018QD009), Wuhan Scientific and Technological Projects (2019020701011441), the Research Fund Program of Guangdong Key Laboratory of Radioactive and Rare Resource Utilization (NO. 2019-LRRRU03), Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology (No: OHIC2019K01). The Key Laboratory of Spectroscopy Sensing, Ministry of Agriculture and Rural Affairs, P. R. China (2020ZJUGP003). Funding Information: This work was supported by grants from National Research Foundation of Korea (CRI project: 2018R1A3B1052702 and 2019M3E5D1A01068998,J.S.K.), and NSFC (21806048,31972744), and the Fundamental Research Funds for the Central Universities (No. 2662018QD009), Wuhan Scientific and Technological Projects (2019020701011441), the Research Fund Program of Guangdong Key Laboratory of Radioactive and Rare Resource Utilization (NO. 2019-LRRRU03), Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology (No: OHIC2019K01). The Key Laboratory of Spectroscopy Sensing, Ministry of Agriculture and Rural Affairs, P. R. China (2020ZJUGP003). Publisher Copyright: © 2020 Elsevier B.V.

PY - 2021/1/15

Y1 - 2021/1/15

N2 - Reactive oxygen species (ROS), thiols and enzymes are regarded as important biomarkers in the physiological process. The abnormal levels of the above species are associated with many diseases, developing a fluorescence detection method for biomarkers is of great significance for diseases early diagnosis and therapy. Compared with traditional fluorescent dyes, aggregation-induced emission (AIE) based fluorescent emitters display excellent photostability with minimum aggregation caused quenching (ACQ) effect. Thus, the biomarker-activable AIEgens have attracted much attentions in biomedical research. In addition, many AIE emitters not only act as fluorescent dyes, but serve as promising theranostic agents. The AIE based image-guided multifunctional theranostics under the activation of biomarkers are vital to the precise biomedicine. This view focuses on the recent development of ROS, thiols, and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics.

AB - Reactive oxygen species (ROS), thiols and enzymes are regarded as important biomarkers in the physiological process. The abnormal levels of the above species are associated with many diseases, developing a fluorescence detection method for biomarkers is of great significance for diseases early diagnosis and therapy. Compared with traditional fluorescent dyes, aggregation-induced emission (AIE) based fluorescent emitters display excellent photostability with minimum aggregation caused quenching (ACQ) effect. Thus, the biomarker-activable AIEgens have attracted much attentions in biomedical research. In addition, many AIE emitters not only act as fluorescent dyes, but serve as promising theranostic agents. The AIE based image-guided multifunctional theranostics under the activation of biomarkers are vital to the precise biomedicine. This view focuses on the recent development of ROS, thiols, and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics.

KW - Activable AIEgens

KW - Aggregation-induced emission

KW - Fluorescence Imaging

KW - Small-molecule dye

KW - Theranostics

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U2 - 10.1016/j.ccr.2020.213559

DO - 10.1016/j.ccr.2020.213559

M3 - Review article

AN - SCOPUS:85090933435

SN - 0010-8545

VL - 427

JO - Coordination Chemistry Reviews

JF - Coordination Chemistry Reviews

M1 - 213559

ER -

Reactive oxygen species, thiols and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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