Readily Accessible and Predictable Naphthalene-Based Two-Photon Fluorophore with Full Visible-Color Coverage

Ja Young Koo; Cheol Ho Heo; Young Hee Shin; Dahahm Kim; Chang Su Lim; Bong Rae Cho; Hwan Myung Kim; Seung Bum Park

doi:10.1002/chem.201603496

Readily Accessible and Predictable Naphthalene-Based Two-Photon Fluorophore with Full Visible-Color Coverage

Ja Young Koo, Cheol Ho Heo, Young Hee Shin, Dahahm Kim, Chang Su Lim, Bong Rae Cho, Hwan Myung Kim, Seung Bum Park

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Herein we report 22 acedan-derived, two-photon fluorophores with synthetic feasibility and full coverage of visible wavelength emission. The emission wavelengths were predicted by computational analysis, which enabled us to visualize multicolor images by two-photon excitation with single wavelength, and to design a turn-on, two-photon fluorescence sensor for endogenous H₂O₂in Raw 264.7 macrophage and rat brain hippocampus ex vivo.

Original language	English
Pages (from-to)	14166-14170
Number of pages	5
Journal	Chemistry - A European Journal
Volume	22
Issue number	40
DOIs	https://doi.org/10.1002/chem.201603496
Publication status	Published - 2016 Sept 26
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the Creative Research Initiative Grant (2014R1A3A2030423) and Bio & Medical Technology Development Program (2012M3A9C4048780) funded by the National Research Foundation of Korea (NRF). J.Y.K., Y.-H.S. and D.K. are grateful for the BK21 plus scholarship.

Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

acedan
biosensors
fluorescence
hydrogen peroxide
visible color

ASJC Scopus subject areas

Catalysis
Organic Chemistry

Access to Document

10.1002/chem.201603496

Cite this

@article{283fd5cf563744969a4d8594968ab4f7,

title = "Readily Accessible and Predictable Naphthalene-Based Two-Photon Fluorophore with Full Visible-Color Coverage",

abstract = "Herein we report 22 acedan-derived, two-photon fluorophores with synthetic feasibility and full coverage of visible wavelength emission. The emission wavelengths were predicted by computational analysis, which enabled us to visualize multicolor images by two-photon excitation with single wavelength, and to design a turn-on, two-photon fluorescence sensor for endogenous H2O2in Raw 264.7 macrophage and rat brain hippocampus ex vivo.",

keywords = "acedan, biosensors, fluorescence, hydrogen peroxide, visible color",

author = "Koo, {Ja Young} and Heo, {Cheol Ho} and Shin, {Young Hee} and Dahahm Kim and Lim, {Chang Su} and Cho, {Bong Rae} and Kim, {Hwan Myung} and Park, {Seung Bum}",

note = "Funding Information: This work was supported by the Creative Research Initiative Grant (2014R1A3A2030423) and Bio & Medical Technology Development Program (2012M3A9C4048780) funded by the National Research Foundation of Korea (NRF). J.Y.K., Y.-H.S. and D.K. are grateful for the BK21 plus scholarship. Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2016",

month = sep,

day = "26",

doi = "10.1002/chem.201603496",

language = "English",

volume = "22",

pages = "14166--14170",

journal = "Chemistry - A European Journal",

issn = "0947-6539",

publisher = "Wiley-VCH Verlag",

number = "40",

}

TY - JOUR

T1 - Readily Accessible and Predictable Naphthalene-Based Two-Photon Fluorophore with Full Visible-Color Coverage

AU - Koo, Ja Young

AU - Heo, Cheol Ho

AU - Shin, Young Hee

AU - Kim, Dahahm

AU - Lim, Chang Su

AU - Cho, Bong Rae

AU - Kim, Hwan Myung

AU - Park, Seung Bum

N1 - Funding Information: This work was supported by the Creative Research Initiative Grant (2014R1A3A2030423) and Bio & Medical Technology Development Program (2012M3A9C4048780) funded by the National Research Foundation of Korea (NRF). J.Y.K., Y.-H.S. and D.K. are grateful for the BK21 plus scholarship. Publisher Copyright: © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2016/9/26

Y1 - 2016/9/26

N2 - Herein we report 22 acedan-derived, two-photon fluorophores with synthetic feasibility and full coverage of visible wavelength emission. The emission wavelengths were predicted by computational analysis, which enabled us to visualize multicolor images by two-photon excitation with single wavelength, and to design a turn-on, two-photon fluorescence sensor for endogenous H2O2in Raw 264.7 macrophage and rat brain hippocampus ex vivo.

AB - Herein we report 22 acedan-derived, two-photon fluorophores with synthetic feasibility and full coverage of visible wavelength emission. The emission wavelengths were predicted by computational analysis, which enabled us to visualize multicolor images by two-photon excitation with single wavelength, and to design a turn-on, two-photon fluorescence sensor for endogenous H2O2in Raw 264.7 macrophage and rat brain hippocampus ex vivo.

KW - acedan

KW - biosensors

KW - fluorescence

KW - hydrogen peroxide

KW - visible color

UR - http://www.scopus.com/inward/record.url?scp=84982237087&partnerID=8YFLogxK

U2 - 10.1002/chem.201603496

DO - 10.1002/chem.201603496

M3 - Article

AN - SCOPUS:84982237087

SN - 0947-6539

VL - 22

SP - 14166

EP - 14170

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 40

ER -

Readily Accessible and Predictable Naphthalene-Based Two-Photon Fluorophore with Full Visible-Color Coverage

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this