Real-time quantitative monitoring of specific peptide cleavage by a proteinase for cancer diagnosis

Gyudo Lee; Kilho Eom; Joseph Park; Jaemoon Yang; Seungjoo Haam; Yong Min Huh; Joo Kyung Ryu; Nam Hee Kim; Jong In Yook; Sang Woo Lee; Dae Sung Yoon; Taeyun Kwon

doi:10.1002/anie.201108830

Real-time quantitative monitoring of specific peptide cleavage by a proteinase for cancer diagnosis

Gyudo Lee, Kilho Eom, Joseph Park, Jaemoon Yang, Seungjoo Haam, Yong Min Huh, Joo Kyung Ryu, Nam Hee Kim, Jong In Yook, Sang Woo Lee, Dae Sung Yoon, Taeyun Kwon

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Good vibrations: A bioassay using a resonant peptide-functionalized microcantilever enables the quantitative characterization of the proteolytic activity of membrane type-1 matrix metalloproteinase (MT1-MMP). In this assay, shifts in the frequency of the cantilever after specific proteolytic cleavage of the target peptides by MT1-MMP are measured (see picture).

Original language	English
Pages (from-to)	5837-5841
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	24
DOIs	https://doi.org/10.1002/anie.201108830
Publication status	Published - 2012 Jun 11
Externally published	Yes

Keywords

atomic force microscopy
biosensors
cancer
peptides
proteases

ASJC Scopus subject areas

Catalysis
Chemistry(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201108830

Cite this

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title = "Real-time quantitative monitoring of specific peptide cleavage by a proteinase for cancer diagnosis",

abstract = "Good vibrations: A bioassay using a resonant peptide-functionalized microcantilever enables the quantitative characterization of the proteolytic activity of membrane type-1 matrix metalloproteinase (MT1-MMP). In this assay, shifts in the frequency of the cantilever after specific proteolytic cleavage of the target peptides by MT1-MMP are measured (see picture).",

keywords = "atomic force microscopy, biosensors, cancer, peptides, proteases",

author = "Gyudo Lee and Kilho Eom and Joseph Park and Jaemoon Yang and Seungjoo Haam and Huh, {Yong Min} and Ryu, {Joo Kyung} and Kim, {Nam Hee} and Yook, {Jong In} and Lee, {Sang Woo} and Yoon, {Dae Sung} and Taeyun Kwon",

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month = jun,

day = "11",

doi = "10.1002/anie.201108830",

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journal = "Angewandte Chemie - International Edition",

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T1 - Real-time quantitative monitoring of specific peptide cleavage by a proteinase for cancer diagnosis

AU - Lee, Gyudo

AU - Eom, Kilho

AU - Park, Joseph

AU - Yang, Jaemoon

AU - Haam, Seungjoo

AU - Huh, Yong Min

AU - Ryu, Joo Kyung

AU - Kim, Nam Hee

AU - Yook, Jong In

AU - Lee, Sang Woo

AU - Yoon, Dae Sung

AU - Kwon, Taeyun

PY - 2012/6/11

Y1 - 2012/6/11

N2 - Good vibrations: A bioassay using a resonant peptide-functionalized microcantilever enables the quantitative characterization of the proteolytic activity of membrane type-1 matrix metalloproteinase (MT1-MMP). In this assay, shifts in the frequency of the cantilever after specific proteolytic cleavage of the target peptides by MT1-MMP are measured (see picture).

AB - Good vibrations: A bioassay using a resonant peptide-functionalized microcantilever enables the quantitative characterization of the proteolytic activity of membrane type-1 matrix metalloproteinase (MT1-MMP). In this assay, shifts in the frequency of the cantilever after specific proteolytic cleavage of the target peptides by MT1-MMP are measured (see picture).

KW - atomic force microscopy

KW - biosensors

KW - cancer

KW - peptides

KW - proteases

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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ER -

Real-time quantitative monitoring of specific peptide cleavage by a proteinase for cancer diagnosis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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