Abstract
Cell migration is a highly orchestrated cellular event that involves physical interactions of diverse subcellular components. The nucleus as the largest and stiffest organelle in the cell not only maintains genetic functionality, but also actively changes its morphology and translocates through dynamic formation of nucleus-bound contractile stress fibers. Nuclear motion is an active and essential process for successful cell migration and nucleus self-repairs in response to compression and extension forces in complex cell microenvironment. This review recapitulates molecular regulators that are crucial for nuclear motility during cell migration and highlights recent advances in nuclear deformation-mediated rupture and repair processes in a migrating cell.
| Original language | English |
|---|---|
| Pages (from-to) | 50-62 |
| Number of pages | 13 |
| Journal | Cell Adhesion and Migration |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2019 Jan 1 |
Bibliographical note
Funding Information:This work was supported by the National Science Foundation Graduate Research Fellowship (to A.S.) and National Institutes of Health Grants U54CA210173 and R01CA174388 (to D.W.). D.K. appreciates the financial support from KU-KIST Graduate School of Converging Science and Technology Program, Korea University Future Research Grants, and National Research Foundation of Korea (2016R1C1B2015018 and 2017K2A9A1A01092963). Authors thank Dr. Dong-Hwee Kim’s Applied Mechanobiology Group (AMG) at Korea University and Dr. Denis Wirtz’s group at Johns Hopkins University for thoughtful discussion.
Publisher Copyright:
© 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Keywords
- Cell migration
- Cytoskeleton
- LINC complex
- Nuclear mechanics
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Cell Biology