Recent advancements in mixotrophic bioprocessing for production of high value microalgal products

Anil Kumar Patel, Reeta Rani Singhania, Sang Jun Sim, Cheng Di Dong

Research output: Contribution to journalReview articlepeer-review

57 Citations (Scopus)


Recently, microalgal biomass has become an attractive and sustainable feedstock for renewable production of various biochemicals and biofuels. However, attaining required productivity remains a key challenge to develop industrial applications. Fortunately, mixotrophic cultivation strategy (MCS) is leading to higher productivity due to the metabolic ability of some microalgal strain to utilise both photosynthesis and organic carbon compared to phototrophic or heterotrophic processes. The potential of MCS is being explored by researchers for maximized biochemicals and biofuels production however it requires further development yet to reach commercialization stage. In this review, recent developments in the MCS bioprocess for selective value-added (carotenoids) products have been reviewed; synergistic mechanism of carbon and energy was conferred. Moreover, the metabolic regulation of microalgae under MCS for utilized carbon forms and carbon recycling was demonstrated; Additionally, the opportunities and challenges of large-scale MCS have been discussed.

Original languageEnglish
Article number124421
JournalBioresource technology
Publication statusPublished - 2021 Jan

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Ltd


  • Bioproducts
  • MCS
  • Microalgae
  • Mixotrophic
  • Organic carbon
  • Photosynthesis

ASJC Scopus subject areas

  • Bioengineering
  • Environmental Engineering
  • Renewable Energy, Sustainability and the Environment
  • Waste Management and Disposal


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