Recent advances in Gd-chelate based bimodal optical/MRI contrast agents

Peter Verwilst, Soyeon Park, Byungkwon Yoon, Jong Seung Kim

    Research output: Contribution to journalReview articlepeer-review

    147 Citations (Scopus)

    Abstract

    Research on bimodal contrast agents in general and optical/MRI contrast agents in particular has attracted increased attention from the scientific community in recent years. Whereas optical contrast agents reveal pathologies at the cellular or sub-cellular level, MRI contrast agents generally report physiological differences at the level of tissues and organs. The complementary information obtained from these two techniques allows for a more precise diagnosis. Furthermore the emergence of near-infrared luminophores accommodates the simultaneous detection of optical and MRI signals. The current multitude and diversity in molecular architectures mirrors the ever increasing interest in the field. In this review the developments between 2010 and mid-2014 are highlighted.

    Original languageEnglish
    Pages (from-to)1791-1806
    Number of pages16
    JournalChemical Society Reviews
    Volume44
    Issue number7
    DOIs
    Publication statusPublished - 2015 Apr 7

    Bibliographical note

    Publisher Copyright:
    © The Royal Society of Chemistry.

    ASJC Scopus subject areas

    • General Chemistry

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