Recent advances in Gd-chelate based bimodal optical/MRI contrast agents

Peter Verwilst, Soyeon Park, Byungkwon Yoon, Jong Seung Kim

Research output: Contribution to journalReview articlepeer-review

141 Citations (Scopus)


Research on bimodal contrast agents in general and optical/MRI contrast agents in particular has attracted increased attention from the scientific community in recent years. Whereas optical contrast agents reveal pathologies at the cellular or sub-cellular level, MRI contrast agents generally report physiological differences at the level of tissues and organs. The complementary information obtained from these two techniques allows for a more precise diagnosis. Furthermore the emergence of near-infrared luminophores accommodates the simultaneous detection of optical and MRI signals. The current multitude and diversity in molecular architectures mirrors the ever increasing interest in the field. In this review the developments between 2010 and mid-2014 are highlighted.

Original languageEnglish
Pages (from-to)1791-1806
Number of pages16
JournalChemical Society Reviews
Issue number7
Publication statusPublished - 2015 Apr 7

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry.

ASJC Scopus subject areas

  • General Chemistry


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