Abstract
Plasmonic nanogap-enhanced Raman scattering has attracted considerable attention in the fields of Raman-based bioanalytical applications and materials science. Various strategies have been proposed to prepare nanostructures with an inter- or intra-nanogap for fundamental study models or applications. This report focuses on recent advances in synthetic methods to fabricate intra-nanogap structures with diverse dimensions, with detailed focus on the theory and bioanalytical applications. Synthetic strategies ranging from the use of a silica layer to small molecules, the use of polymers and galvanic replacement, are extensively investigated. Furthermore, various core structures, such as spherical, rod-, and cube-shaped, are widely studied, and greatly expand the diversity of plasmonic nanostructures with an intra-nanogap. Theoretical calculations, ranging from the first plasmonic hybridization model that is applied to a concentric Au–SiO2–Au nanosphere to the modern quantum corrected model, have evolved to accurately describe the plasmonic resonance property in concentric core–shell nanostructures with a subnanometer nanogap. The greatly enhanced and uniform Raman responses from the localized Raman reporter in the built-in nanogap have made it possible to achieve promising probes with an extraordinary high sensitivity in various formats, such as biomolecule detection, high-resolution cell imaging, and an in vivo imaging application.
Original language | English |
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Article number | 2002219 |
Journal | Advanced Materials |
Volume | 32 |
Issue number | 51 |
DOIs | |
Publication status | Published - 2020 Dec 22 |
Bibliographical note
Funding Information:The authors acknowledge financial support from a Korea University Grant and from the KU‐KIST research fund. This research was also supported by the National Research Foundation of Korea (No. NRF‐2017M3D1A1039421 and 2018R1A2A3075499).
Funding Information:
The authors acknowledge financial support from a Korea University Grant and from the KU-KIST research fund. This research was also supported by the National Research Foundation of Korea (No. NRF-2017M3D1A1039421 and 2018R1A2A3075499).
Publisher Copyright:
© 2020 Wiley-VCH GmbH
Keywords
- intra-nanogap structures
- oligonucleotides
- quantum tunneling
- small molecules
- surface-enhanced Raman scattering
ASJC Scopus subject areas
- General Materials Science
- Mechanics of Materials
- Mechanical Engineering