Recent Advances in the Synthesis of Intra-Nanogap Au Plasmonic Nanostructures for Bioanalytical Applications

Wonseok Yang, Dong Kwon Lim

    Research output: Contribution to journalReview articlepeer-review

    46 Citations (Scopus)

    Abstract

    Plasmonic nanogap-enhanced Raman scattering has attracted considerable attention in the fields of Raman-based bioanalytical applications and materials science. Various strategies have been proposed to prepare nanostructures with an inter- or intra-nanogap for fundamental study models or applications. This report focuses on recent advances in synthetic methods to fabricate intra-nanogap structures with diverse dimensions, with detailed focus on the theory and bioanalytical applications. Synthetic strategies ranging from the use of a silica layer to small molecules, the use of polymers and galvanic replacement, are extensively investigated. Furthermore, various core structures, such as spherical, rod-, and cube-shaped, are widely studied, and greatly expand the diversity of plasmonic nanostructures with an intra-nanogap. Theoretical calculations, ranging from the first plasmonic hybridization model that is applied to a concentric Au–SiO2–Au nanosphere to the modern quantum corrected model, have evolved to accurately describe the plasmonic resonance property in concentric core–shell nanostructures with a subnanometer nanogap. The greatly enhanced and uniform Raman responses from the localized Raman reporter in the built-in nanogap have made it possible to achieve promising probes with an extraordinary high sensitivity in various formats, such as biomolecule detection, high-resolution cell imaging, and an in vivo imaging application.

    Original languageEnglish
    Article number2002219
    JournalAdvanced Materials
    Volume32
    Issue number51
    DOIs
    Publication statusPublished - 2020 Dec 22

    Bibliographical note

    Funding Information:
    The authors acknowledge financial support from a Korea University Grant and from the KU‐KIST research fund. This research was also supported by the National Research Foundation of Korea (No. NRF‐2017M3D1A1039421 and 2018R1A2A3075499).

    Funding Information:
    The authors acknowledge financial support from a Korea University Grant and from the KU-KIST research fund. This research was also supported by the National Research Foundation of Korea (No. NRF-2017M3D1A1039421 and 2018R1A2A3075499).

    Publisher Copyright:
    © 2020 Wiley-VCH GmbH

    Keywords

    • intra-nanogap structures
    • oligonucleotides
    • quantum tunneling
    • small molecules
    • surface-enhanced Raman scattering

    ASJC Scopus subject areas

    • General Materials Science
    • Mechanics of Materials
    • Mechanical Engineering

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