Recent progress in multifunctional conjugated polymer nanomaterial-based synergistic combination phototherapy for microbial infection theranostics

Panchanathan Manivasagan, Jungbae Kim, Eue Soon Jang

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)

Abstract

Microbial infection is a critical public health problem, owing to its strong infectivity and high risk of mortality. Multi-antibiotic resistant pathogens reduce the efficacy of commercial antibiotics, thereby worsening microbial infections. New antimicrobial nanomaterials (e.g., conjugated polymer-based nanomaterials) and strategies (e.g., phototherapy) must be developed for the early diagnosis and effective elimination of microbial infections. Conjugated polymers are a versatile class of biomaterials, possessing diverse structures and functionalities for biomedical applications, owing to their excellent biocompatibility, stability, and easily modifiable surface properties. Recently, conjugated polymer-based nanomaterials have emerged as phototherapy agents to treat multi-antibiotic resistant infections. To the best of our knowledge, no study has comprehensively discussed conjugated polymer-based nanomaterials as photoactive agents for multimodal imaging-guided combination phototherapy against microbial infections. This review provides an in-depth summary of the recent progress in multifunctional conjugated polymer-based nanomaterials for photo-based diagnostic and therapeutic applications to treat infections caused multi-drug resistant pathogens. Conjugated polymer nanomaterial-based phototherapy will offer a better platform for future microbial infection theranostics.

Original languageEnglish
Article number214701
JournalCoordination Chemistry Reviews
Volume470
DOIs
Publication statusPublished - 2022 Nov 1

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2020R1A2C3009649). This research was supported by the BK21 FOUR Program (4199990414461) funded by the Ministry of Education (MOE, Korea) and the National Research Foundation of Korea (NRF). Prof. Eue-Soon Jang is especially thankful for research grants from the Korean Ministry of Education, Science &Technology (2016R1D1A3B0201175615) and the Grand Information Technology Research Center Program (IITP-2022-2020-0-01612) through the Institute of Information &Communications Technology Planning &Evaluation (IITP) funded by the Ministry of Science and ICT (MSIT), Republic of Korea. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2022R1I1A1A01068693). Prof. Eue-Soon Jang is especially thankful for research grants from the Korean Ministry of Education, Science & Technology (2016R1D1A3B0201175615) and the Grand Information Technology Research Center Program (IITP-2022-2020-0-01612) through the Institute of Information & Communications Technology Planning & Evaluation (IITP) funded by the Ministry of Science and ICT (MSIT), Republic of Korea.

Publisher Copyright:
© 2022 Elsevier B.V.

Keywords

  • Microbial infection
  • Nanomaterial
  • Phototherapy
  • Polymer
  • Theranostic

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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