Recent progress in the engineering of C1-utilizing microbes

Jiyun Bae, Sangrak Jin, Seulgi Kang, Byung Kwan Cho, Min Kyu Oh

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


The global climate crisis has led to the transition toward the sustainable production of chemicals and fuels with a low carbon footprint. Microbial utilization of one-carbon (C1) substrates, such as carbon dioxide, carbon monoxide, methane, formate, and methanol, may be a promising replacement for the current fossil fuel-based industry. However, natural C1-utilizing microbes are currently unsuitable for industrial applications because of their slow growth and low carbon conversion efficiency, which results in low productivity and yield. Here, we review the recent achievements in engineering C1-utilizing microbes with improved carbon assimilation efficiency and describe the development of synthetic microorganisms by introducing natural C1 assimilation pathways in non-C1-utilizing microbes. Finally, we outline the future directions for realizing the industrial potential of C1-utilizing microbes.

Original languageEnglish
Article number102836
JournalCurrent Opinion in Biotechnology
Publication statusPublished - 2022 Dec

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering


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