Recombinant newcastle disease virus as a vaccine vector

T. Nakaya; J. Cros; M. S. Park; Y. Nakaya; H. Zheng; A. Sagrera; E. Villar; A. García-Sastre; P. Palese

doi:10.1128/JVI.75.23.11868-11873.2001

Recombinant newcastle disease virus as a vaccine vector

T. Nakaya
, J. Cros
, M. S. Park
, Y. Nakaya
, H. Zheng
, A. Sagrera
, E. Villar
, A. García-Sastre
, P. Palese^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

220 Citations (Scopus)

Abstract

A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. The rescued virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus challenge in mice, demonstrating the potential of recombinant NDV as a vaccine vector.

Original language	English
Pages (from-to)	11868-11873
Number of pages	6
Journal	Journal of virology
Volume	75
Issue number	23
DOIs	https://doi.org/10.1128/JVI.75.23.11868-11873.2001
Publication status	Published - 2001
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/JVI.75.23.11868-11873.2001

Cite this

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title = "Recombinant newcastle disease virus as a vaccine vector",

abstract = "A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. The rescued virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus challenge in mice, demonstrating the potential of recombinant NDV as a vaccine vector.",

author = "T. Nakaya and J. Cros and Park, \{M. S.\} and Y. Nakaya and H. Zheng and A. Sagrera and E. Villar and A. Garc{\'i}a-Sastre and P. Palese",

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T1 - Recombinant newcastle disease virus as a vaccine vector

AU - Nakaya, T.

AU - Cros, J.

AU - Park, M. S.

AU - Nakaya, Y.

AU - Zheng, H.

AU - Sagrera, A.

AU - Villar, E.

AU - García-Sastre, A.

AU - Palese, P.

PY - 2001

Y1 - 2001

N2 - A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. The rescued virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus challenge in mice, demonstrating the potential of recombinant NDV as a vaccine vector.

AB - A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. The rescued virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus challenge in mice, demonstrating the potential of recombinant NDV as a vaccine vector.

UR - https://www.scopus.com/pages/publications/0035164225

U2 - 10.1128/JVI.75.23.11868-11873.2001

DO - 10.1128/JVI.75.23.11868-11873.2001

M3 - Article

C2 - 11689668

AN - SCOPUS:0035164225

SN - 0022-538X

VL - 75

SP - 11868

EP - 11873

JO - Journal of virology

JF - Journal of virology

IS - 23

ER -

Recombinant newcastle disease virus as a vaccine vector

Abstract

UN SDGs

ASJC Scopus subject areas

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