Reduced orbitofrontal-thalamic functional connectivity related to suicidal ideation in patients with major depressive disorder

Kiwon Kim, Sung Woo Kim, Woojae Myung, Cheol E. Han, Maurizio Fava, David Mischoulon, George I. Papakostas, Sang Won Seo, Hana Cho, Joon Kyung Seong, Hong Jin Jeon

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Abstract

Despite recent developments in neuroimaging, alterations of brain functional connectivity in major depressive disorder (MDD) patients with suicidal ideation are poorly understood. This study investigated specific changes of suicidal ideation in functional connectivity of MDD patients. Whole brain functional connectivity in 46 patients with MDD (23 with suicidal ideation and 23 without) and 36 age- and gender- matched healthy controls were compared using resting-state functional Magnetic Resonance Imaging (fMRI) analyzed with network-based statistics (NBS) and graph-theoretical methods. Decreased functional connectivity in a characterized sub-network was observed in patients with MDD and suicidal ideation (FDR-adjusted p < 0.05). The sub-network included the regions of the fronto-thalamic circuits in the left hemisphere. The network measures of the left superior frontal gyrus, pars orbitalis (r = -0.40, p = 0.009), left thalamus (r = -0.41, p = 0.009), and right thalamus (r = -0.51, p = -0.002) were shown, through graph theoretical analysis, to be significantly negatively correlated with severity of suicidal ideation. The reduced functional connectivity in left orbitofrontal-both thalamic regions with suicidal ideation in MDD were inversely proportional to the severity of suicidality independent from depression severity. These findings suggest problems with decision-making and information integration in MDD patients with suicidal ideation.

Original languageEnglish
Article number15772
JournalScientific reports
Volume7
Issue number1
DOIs
Publication statusPublished - 2017 Dec 1

Bibliographical note

Funding Information:
This research was mainly supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) (No. 2011–0013064, PI: HJJ) and the Original Technology Research Program for Brain Science through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (No. NRF-2016M3C7A1947307; PI HJJ), and the Bio & Medical Technology Development Program of the NRF funded by the Korean government, MSIP (No. NRF-2017M3A9F1027323; PI HJJ). This study was also supported by Samsung Medical Center grant (SMO1161491, PI: Hong Jin Jeon), the NRF of Korea grant funded by the Korea government (MSIP-2011–0013064 to W.M.), Brain Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2017M3C7A1048092 to Joon-Kyung Seong), and the Original Technology Research Program for Brain Science through the National Research Foundation of Korea (NRF) funded by the Ministry of Science ICT and Future Planning (2017M3C7A1048566 to Joon-Kyung Seong). These funding sources were not involved in the creation of the study protocol, data analysis, or in writing the manuscript.

Publisher Copyright:
© 2017 The Author(s).

ASJC Scopus subject areas

  • General

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