TY - JOUR
T1 - Reduced white matter integrity in antisocial personality disorder
T2 - A diffusion tensor imaging study
AU - Jiang, Weixiong
AU - Shi, Feng
AU - Liu, Huasheng
AU - Li, Gang
AU - Ding, Zhongxiang
AU - Shen, Hui
AU - Shen, Celina
AU - Lee, Seong Whan
AU - Hu, Dewen
AU - Wang, Wei
AU - Shen, Dinggang
N1 - Funding Information:
The China Postdoctoral Science Foundation (2015M582879), Research Foundation of Education Bureau of Hunan Province (16A043) and Key Laboratory of Basic Education Information Technology of Hunan Province (2015TP1017) helped support this work. Additionally, this study was partially supported by the National Natural Science Foundation of China (61420106001, 61375111, 81571298) and, in part, supported by NIH grants (AG041721, MH107815, MH108914, EB006733, EB008374, EB009634).
Publisher Copyright:
© The Author(s) 2017.
PY - 2017/2/22
Y1 - 2017/2/22
N2 - Emerging neuroimaging research suggests that antisocial personality disorder (ASPD) may be linked to abnormal brain anatomy, but little is known about possible impairments of white matter microstructure in ASPD, as well as their relationship with impulsivity or risky behaviors. In this study, we systematically investigated white matter abnormalities of ASPD using diffusion tensor imaging (DTI) measures: fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD). Then, we further investigated their correlations with the scores of impulsivity or risky behaviors. ASPD patients showed decreased FA in multiple major white matter fiber bundles, which connect the fronto-parietal control network and the fronto-temporal network. We also found AD/RD deficits in some additional white matter tracts that were not detected by FA. More interestingly, several regions were found correlated with impulsivity or risky behaviors in AD and RD values, although not in FA values, including the splenium of corpus callosum, left posterior corona radiate/posterior thalamic radiate, right superior longitudinal fasciculus, and left inferior longitudinal fasciculus. These regions can be the potential biomarkers, which would be of great interest in further understanding the pathomechanism of ASPD.
AB - Emerging neuroimaging research suggests that antisocial personality disorder (ASPD) may be linked to abnormal brain anatomy, but little is known about possible impairments of white matter microstructure in ASPD, as well as their relationship with impulsivity or risky behaviors. In this study, we systematically investigated white matter abnormalities of ASPD using diffusion tensor imaging (DTI) measures: fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD). Then, we further investigated their correlations with the scores of impulsivity or risky behaviors. ASPD patients showed decreased FA in multiple major white matter fiber bundles, which connect the fronto-parietal control network and the fronto-temporal network. We also found AD/RD deficits in some additional white matter tracts that were not detected by FA. More interestingly, several regions were found correlated with impulsivity or risky behaviors in AD and RD values, although not in FA values, including the splenium of corpus callosum, left posterior corona radiate/posterior thalamic radiate, right superior longitudinal fasciculus, and left inferior longitudinal fasciculus. These regions can be the potential biomarkers, which would be of great interest in further understanding the pathomechanism of ASPD.
UR - http://www.scopus.com/inward/record.url?scp=85013654972&partnerID=8YFLogxK
U2 - 10.1038/srep43002
DO - 10.1038/srep43002
M3 - Article
C2 - 28223713
AN - SCOPUS:85013654972
SN - 2045-2322
VL - 7
JO - Scientific reports
JF - Scientific reports
M1 - 43002
ER -