Reduction-Responsive Supramolecular Sheets for Selective Regulation of Facultative Anaerobe Agglutination

Dawoon Lee, Longlong Dong, Ye Rim Kim, Jehan Kim, Myongsoo Lee, Yongju Kim

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Stimuli-responsive supramolecular materials have promising biological applications because of their ability to rapidly undergo significant structural changes in response to diverse stimuli. Herein, supramolecular sheets assembled via charge-transfer interactions between the pyrene moiety of a d-mannose-containing amphiphile and 7,7,8,8-tetracyanoquinodimethane (TCNQ) are reported. The supramolecular sheets show reduction-responsive behavior, in which their disassembly is triggered by the reduction of TCNQ by sodium sulfide. In an anaerobic environment, the sheet structure remains intact and the exposed d-mannose moieties induce the agglutination of facultative anaerobes, thereby inhibiting bacterial growth. In contrast, in an aerobic environment, the reduction of TCNQ by the hydrogen sulfide generated by facultative anaerobes causes sheet disassembly. This enables continuous bacterial growth, because the collapsed sheets cannot induce agglutination. Thus, this study presents a novel supramolecular material for the selective regulation of facultative anaerobe growth according to the external environment.

Original languageEnglish
Article number2203136
JournalAdvanced Healthcare Materials
Volume12
Issue number19
DOIs
Publication statusPublished - 2023 Jul 27

Bibliographical note

Publisher Copyright:
© 2023 Wiley-VCH GmbH.

Keywords

  • bacterial agglutination
  • charge-transfer interaction
  • reduction-responsive sheets
  • selective regulation
  • supramolecular materials

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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