Reflex vocal fold adduction in the porcine model: The effects of stimuli delivered to various sensory nerves

Jeong Soo Woo; Jagdeep S. Hundal; Clarence T. Sasaki; Mikhail W. Abdelmessih; Stephen P. Kelleher

doi:10.1177/000348940811701008

Reflex vocal fold adduction in the porcine model: The effects of stimuli delivered to various sensory nerves

Jeong Soo Woo, Jagdeep S. Hundal, Clarence T. Sasaki, Mikhail W. Abdelmessih, Stephen P. Kelleher

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Objectives: The aim of this study was to identify a panel of sensory nerves capable of eliciting an evoked glottic closure reflex (GCR) and to quantify the glottic closing force (GCF) of these responses in a porcine model. Methods: In 5 pigs, the internal branch of the superior laryngeal nerve (iSLN) and the trigeminal, pharyngeal plexus, glossopharyngeal, radial, and intercostal nerves were surgically isolated and electrically stimulated. During stimulation of each nerve, the GCR was detected by laryngeal electromyography and the GCF was measured with a pressure transducer. Results: The only nerve that elicited the GCR in the 5 pigs was the iSLN. The average GCF was 288.9 mm Hg. Conclusions: This study demonstrates that the only afferent nerve that elicits the GCR in pigs is the iSLN, and that it should remain the focus of research for the rehabilitation of patients with absent or defective reflex vocal fold adduction.

Original language	English
Pages (from-to)	749-752
Number of pages	4
Journal	Annals of Otology, Rhinology and Laryngology
Volume	117
Issue number	10
DOIs	https://doi.org/10.1177/000348940811701008
Publication status	Published - 2008 Oct
Externally published	Yes

Bibliographical note

Funding Information:
From the Section of Otolaryngology, Yale School of Medicine, New Haven, Connecticut. Supported in part by the Charles W. Ohse Endowment. This study was performed in accordance with the PHS Policy on Humane Care and Use of Laboratory Animals, the NIH Guide for the Care and Use of Laboratory Animals, and the Animal Welfare Act (7 U.S.C. et seq.); the animal use protocol was approved by the Institutional Animal Care and Use Committee (IACUC) of Yale University.

Keywords

Afferent nerve
Electrical stimulation
Glottis
Neuron
Reflex

ASJC Scopus subject areas

Otorhinolaryngology

Access to Document

10.1177/000348940811701008

Cite this

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title = "Reflex vocal fold adduction in the porcine model: The effects of stimuli delivered to various sensory nerves",

abstract = "Objectives: The aim of this study was to identify a panel of sensory nerves capable of eliciting an evoked glottic closure reflex (GCR) and to quantify the glottic closing force (GCF) of these responses in a porcine model. Methods: In 5 pigs, the internal branch of the superior laryngeal nerve (iSLN) and the trigeminal, pharyngeal plexus, glossopharyngeal, radial, and intercostal nerves were surgically isolated and electrically stimulated. During stimulation of each nerve, the GCR was detected by laryngeal electromyography and the GCF was measured with a pressure transducer. Results: The only nerve that elicited the GCR in the 5 pigs was the iSLN. The average GCF was 288.9 mm Hg. Conclusions: This study demonstrates that the only afferent nerve that elicits the GCR in pigs is the iSLN, and that it should remain the focus of research for the rehabilitation of patients with absent or defective reflex vocal fold adduction.",

keywords = "Afferent nerve, Electrical stimulation, Glottis, Neuron, Reflex",

author = "Woo, {Jeong Soo} and Hundal, {Jagdeep S.} and Sasaki, {Clarence T.} and Abdelmessih, {Mikhail W.} and Kelleher, {Stephen P.}",

note = "Funding Information: From the Section of Otolaryngology, Yale School of Medicine, New Haven, Connecticut. Supported in part by the Charles W. Ohse Endowment. This study was performed in accordance with the PHS Policy on Humane Care and Use of Laboratory Animals, the NIH Guide for the Care and Use of Laboratory Animals, and the Animal Welfare Act (7 U.S.C. et seq.); the animal use protocol was approved by the Institutional Animal Care and Use Committee (IACUC) of Yale University.",

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AU - Sasaki, Clarence T.

AU - Abdelmessih, Mikhail W.

AU - Kelleher, Stephen P.

N1 - Funding Information: From the Section of Otolaryngology, Yale School of Medicine, New Haven, Connecticut. Supported in part by the Charles W. Ohse Endowment. This study was performed in accordance with the PHS Policy on Humane Care and Use of Laboratory Animals, the NIH Guide for the Care and Use of Laboratory Animals, and the Animal Welfare Act (7 U.S.C. et seq.); the animal use protocol was approved by the Institutional Animal Care and Use Committee (IACUC) of Yale University.

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N2 - Objectives: The aim of this study was to identify a panel of sensory nerves capable of eliciting an evoked glottic closure reflex (GCR) and to quantify the glottic closing force (GCF) of these responses in a porcine model. Methods: In 5 pigs, the internal branch of the superior laryngeal nerve (iSLN) and the trigeminal, pharyngeal plexus, glossopharyngeal, radial, and intercostal nerves were surgically isolated and electrically stimulated. During stimulation of each nerve, the GCR was detected by laryngeal electromyography and the GCF was measured with a pressure transducer. Results: The only nerve that elicited the GCR in the 5 pigs was the iSLN. The average GCF was 288.9 mm Hg. Conclusions: This study demonstrates that the only afferent nerve that elicits the GCR in pigs is the iSLN, and that it should remain the focus of research for the rehabilitation of patients with absent or defective reflex vocal fold adduction.

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Reflex vocal fold adduction in the porcine model: The effects of stimuli delivered to various sensory nerves

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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