TY - JOUR
T1 - Reflex vocal fold adduction in the porcine model
T2 - The effects of stimuli delivered to various sensory nerves
AU - Woo, Jeong Soo
AU - Hundal, Jagdeep S.
AU - Sasaki, Clarence T.
AU - Abdelmessih, Mikhail W.
AU - Kelleher, Stephen P.
N1 - Funding Information:
From the Section of Otolaryngology, Yale School of Medicine, New Haven, Connecticut. Supported in part by the Charles W. Ohse Endowment. This study was performed in accordance with the PHS Policy on Humane Care and Use of Laboratory Animals, the NIH Guide for the Care and Use of Laboratory Animals, and the Animal Welfare Act (7 U.S.C. et seq.); the animal use protocol was approved by the Institutional Animal Care and Use Committee (IACUC) of Yale University.
PY - 2008/10
Y1 - 2008/10
N2 - Objectives: The aim of this study was to identify a panel of sensory nerves capable of eliciting an evoked glottic closure reflex (GCR) and to quantify the glottic closing force (GCF) of these responses in a porcine model. Methods: In 5 pigs, the internal branch of the superior laryngeal nerve (iSLN) and the trigeminal, pharyngeal plexus, glossopharyngeal, radial, and intercostal nerves were surgically isolated and electrically stimulated. During stimulation of each nerve, the GCR was detected by laryngeal electromyography and the GCF was measured with a pressure transducer. Results: The only nerve that elicited the GCR in the 5 pigs was the iSLN. The average GCF was 288.9 mm Hg. Conclusions: This study demonstrates that the only afferent nerve that elicits the GCR in pigs is the iSLN, and that it should remain the focus of research for the rehabilitation of patients with absent or defective reflex vocal fold adduction.
AB - Objectives: The aim of this study was to identify a panel of sensory nerves capable of eliciting an evoked glottic closure reflex (GCR) and to quantify the glottic closing force (GCF) of these responses in a porcine model. Methods: In 5 pigs, the internal branch of the superior laryngeal nerve (iSLN) and the trigeminal, pharyngeal plexus, glossopharyngeal, radial, and intercostal nerves were surgically isolated and electrically stimulated. During stimulation of each nerve, the GCR was detected by laryngeal electromyography and the GCF was measured with a pressure transducer. Results: The only nerve that elicited the GCR in the 5 pigs was the iSLN. The average GCF was 288.9 mm Hg. Conclusions: This study demonstrates that the only afferent nerve that elicits the GCR in pigs is the iSLN, and that it should remain the focus of research for the rehabilitation of patients with absent or defective reflex vocal fold adduction.
KW - Afferent nerve
KW - Electrical stimulation
KW - Glottis
KW - Neuron
KW - Reflex
UR - http://www.scopus.com/inward/record.url?scp=54249095507&partnerID=8YFLogxK
U2 - 10.1177/000348940811701008
DO - 10.1177/000348940811701008
M3 - Article
C2 - 18998503
AN - SCOPUS:54249095507
SN - 0003-4894
VL - 117
SP - 749
EP - 752
JO - Annals of Otology, Rhinology and Laryngology
JF - Annals of Otology, Rhinology and Laryngology
IS - 10
ER -