Regeneration of chronic myocardial infarction by injectable hydrogels containing stem cell homing factor SDF-1 and angiogenic peptide Ac-SDKP

Myeongjin Song; Hwanseok Jang; Jaeyeon Lee; Ji Hyun Kim; Soo Hyun Kim; Kyung Sun; Yongdoo Park

doi:10.1016/j.biomaterials.2013.12.011

Regeneration of chronic myocardial infarction by injectable hydrogels containing stem cell homing factor SDF-1 and angiogenic peptide Ac-SDKP

Myeongjin Song, Hwanseok Jang, Jaeyeon Lee, Ji Hyun Kim, Soo Hyun Kim, Kyung Sun, Yongdoo Park

Research output: Contribution to journal › Article › peer-review

109 Citations (Scopus)

Abstract

Regeneration of chronic myocardial infarction (CMI) is one of the challenging issues due to its limited regeneration activity compared to acute or sub-acute stage. In this study, we examined whether combination of stem cell homing factor (SDF-1) and angiogenic peptides (Ac-SDKP) injected with biomimetic hydrogels promote regeneration of cardiac function in a CMI model. We evaluated the regeneration of chronically infarcted myocardium using injectable biomimetic hydrogels containing two therapeutic factors; stromal-derived factor-1 (SDF-1) and Ac-SDKP for stem cell homing and angiogenesis, respectively. Injection of the two therapeutic factors into the infarct region of the left ventricle showed that the biomimetic hydrogels containing two therapeutic factor exhibited significantly improved left ventricle function, increased angiogenesis, decreased infarct size and greatest wall thickness within the infarct region at 4 weeks post-treatment. From these results, it is clear that hydrogels containing two therapeutic factors showed synergistic effects on regeneration in the chronic heart failure model. In conclusion, these results suggest that combination of stem cell homing factor with angiogenic peptides recruit stem cells to the microenvironments, increase the expression of angiogenic genes, enhance the matured vessel formation and improve the cardiac function in chronic MI.

Original language	English
Pages (from-to)	2436-2445
Number of pages	10
Journal	Biomaterials
Volume	35
Issue number	8
DOIs	https://doi.org/10.1016/j.biomaterials.2013.12.011
Publication status	Published - 2014 Mar

Bibliographical note

Funding Information:
This study was supported by the grant from the National Research Foundation of Korea, Republic of Korea (Grant No. 2011-0016715 ).

Keywords

Ac-SDKP
Chronic heart failure
Controlled release system
Hydrogel
Matrix metalloproteinase (MMP)
SDF-1

ASJC Scopus subject areas

Biophysics
Bioengineering
Ceramics and Composites
Biomaterials
Mechanics of Materials

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10.1016/j.biomaterials.2013.12.011

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title = "Regeneration of chronic myocardial infarction by injectable hydrogels containing stem cell homing factor SDF-1 and angiogenic peptide Ac-SDKP",

abstract = "Regeneration of chronic myocardial infarction (CMI) is one of the challenging issues due to its limited regeneration activity compared to acute or sub-acute stage. In this study, we examined whether combination of stem cell homing factor (SDF-1) and angiogenic peptides (Ac-SDKP) injected with biomimetic hydrogels promote regeneration of cardiac function in a CMI model. We evaluated the regeneration of chronically infarcted myocardium using injectable biomimetic hydrogels containing two therapeutic factors; stromal-derived factor-1 (SDF-1) and Ac-SDKP for stem cell homing and angiogenesis, respectively. Injection of the two therapeutic factors into the infarct region of the left ventricle showed that the biomimetic hydrogels containing two therapeutic factor exhibited significantly improved left ventricle function, increased angiogenesis, decreased infarct size and greatest wall thickness within the infarct region at 4 weeks post-treatment. From these results, it is clear that hydrogels containing two therapeutic factors showed synergistic effects on regeneration in the chronic heart failure model. In conclusion, these results suggest that combination of stem cell homing factor with angiogenic peptides recruit stem cells to the microenvironments, increase the expression of angiogenic genes, enhance the matured vessel formation and improve the cardiac function in chronic MI.",

keywords = "Ac-SDKP, Chronic heart failure, Controlled release system, Hydrogel, Matrix metalloproteinase (MMP), SDF-1",

author = "Myeongjin Song and Hwanseok Jang and Jaeyeon Lee and Kim, {Ji Hyun} and Kim, {Soo Hyun} and Kyung Sun and Yongdoo Park",

note = "Funding Information: This study was supported by the grant from the National Research Foundation of Korea, Republic of Korea (Grant No. 2011-0016715 ). ",

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AU - Song, Myeongjin

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AU - Lee, Jaeyeon

AU - Kim, Ji Hyun

AU - Kim, Soo Hyun

AU - Sun, Kyung

AU - Park, Yongdoo

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Regeneration of chronic myocardial infarction by injectable hydrogels containing stem cell homing factor SDF-1 and angiogenic peptide Ac-SDKP

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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