Regional amyloid burden and lacune in pure subcortical vascular cognitive impairment

Yun Jeong Hong, Chan Mi Kim, Ji Eun Kim, Jee Hoon Roh, Jae Seung Kim, Sang Won Seo, Duk L. Na, Jae Hong Lee

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


We investigated the amyloid and vascular burden in Pittsburgh compound B (PiB)–negative subcortical vascular mild cognitive impairment (svMCI) and PiB-negative subcortical ischemic vascular dementia (SIVD) to elucidate the potential roles of amyloid deposition and small vessel disease (SVD). Thirty-eight svMCI patients and 42 SIVD patients were enrolled. The regional PiB uptake values and SVD markers were obtained and compared between groups. Additionally, correlations among amyloid burden, SVD, and cognition were made. Patients with PiB-negative SIVD showed more amyloid deposition than those with PiB-negative svMCI, particularly in the cuneus, lingual gyrus, supramarginal, and angular gyri. Despite subthreshold levels for amyloid deposition, our findings showed a marked regional difference in amyloid uptake between svMCI and SIVD, particularly in posteriorly located brain areas. However, lacune, a proxy for vascular burden, showed a broader association with cognition and had more impacts on developing dementia than amyloid burden. The topographical pattern of amyloid deposition and its impact on clinical status in pure subcortical vascular cognitive impairment were different from those in Alzheimer's disease.

Original languageEnglish
Pages (from-to)20-26
Number of pages7
JournalNeurobiology of Aging
Publication statusPublished - 2017 Jul 1
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Inc.


  • Amyloid
  • Cerebral small vessel disease
  • Pittsburgh compound B
  • Subcortical ischemic vascular dementia
  • Subcortical vascular mild cognitive impairment
  • Vascular cognitive impairment

ASJC Scopus subject areas

  • General Neuroscience
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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