Regional cortical thinning of the orbitofrontal cortex in medication-naïve female patients with major depressive disorder is not associated with MAOA-uVNTR polymorphism

Eunsoo Won, Sunyoung Choi, June Kang, Min Soo Lee, Byung Joo Ham

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8 Citations (Scopus)

Abstract

Background: Orbitofrontal cortex alterations have been suggested to underlie the impaired mood regulation in depression. MAOA-uVNTR (monoamine oxidase A-upstream variable number of tandem repeats) polymorphism has been reported to be associated with major depressive disorder by various studies. The influence of MAOA-uVNTR genotype on function and structure of the orbitofrontal cortex has previously been reported. In this study, we investigated the difference in orbitofrontal cortex thickness between medication-naïve female patients with major depressive disorder and healthy controls, and the influence of MAOA-uVNTR genotype on orbitofrontal cortex thickness in depression. Methods: Thirty-one patients with major depressive disorder and 43 healthy controls were included. All participants were subjected to T1-weighted structural magnetic resonance imaging and genotyped for MAOA-uVNTR polymorphism. An automated procedure of FreeSurfer was used to analyze difference in orbitofrontal cortex thickness. Results: Patients showed a significantly thinner left orbitofrontal cortex (F (1,71) = 7.941, p = 0.006) and right orbitofrontal cortex (F (1,71) = 17.447, p < 0.001). For the orbitofrontal cortex sub-region analysis, patients showed a significantly thinner left medial orbitofrontal cortex (F (1,71) = 8.117, p = 0.006), right medial orbitofrontal cortex (F (1,71) = 21.795, p < 0.001) and right lateral orbitofrontal cortex (F (1,71) = 9.932, p = 0.002) compared to healthy controls. No significant interaction of diagnosis and MAOA-uVNTR genotype on orbitofrontal cortex thickness was revealed. Conclusions: Our results suggest that structural alterations of the orbitofrontal cortex may be associated with the pathophysiology of major depressive disorder. Future studies with larger sample sizes are needed to detect a possible association between MAOA-uVNTR genotype and orbitofrontal cortex thickness in depression.

Original languageEnglish
Article number26
JournalAnnals of General Psychiatry
Volume15
Issue number1
DOIs
Publication statusPublished - 2016 Oct 12

Bibliographical note

Funding Information:
This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Educa‑ tion, Science and Technology (NRF‑2011‑0023272) and the Korean Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (HI12C0003). The funder had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.

Publisher Copyright:
© 2016 The Author(s).

Keywords

  • Major depressive disorder
  • Monoamine oxidase A-upstream variable number of tandem repeats
  • Orbitofrontal cortex thickness

ASJC Scopus subject areas

  • Psychiatry and Mental health

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