Regional glucose metabolism due to the presence of cerebral amyloidopathy in older adults with depression and mild cognitive impairment

Hyun Chul Youn; Eun Seong Lee; Suji Lee; Sangil Suh; Hyun Ghang Jeong; Jae Seon Eo

doi:10.1016/j.jad.2018.06.029

Regional glucose metabolism due to the presence of cerebral amyloidopathy in older adults with depression and mild cognitive impairment

Hyun Chul Youn, Eun Seong Lee, Suji Lee, Sangil Suh, Hyun Ghang Jeong, Jae Seon Eo

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Background: Depression is a risk factor for mild cognitive impairment (MCI) and for the conversion from MCI to Alzheimer's disease (AD). This study investigated regional cerebral glucose metabolism (rCMglc) in older adults with depression and MCI, either with or without amyloidopathy. Methods: We recruited 31 older adults diagnosed with depression and MCI, and 21 older adults with normal cognition (NC). All participants completed demographic questionnaires and were examined with a standardized neuropsychological battery, F-18 fluorodeoxyglucose positron emission tomography (PET), and F-18 florbetaben PET. We classified subjects with depression and MCI into amyloid-β-positive (CDAP; n = 16) and amyloid-β-negative (CDAN; n = 15) groups. Pairwise rCMglc analyses were conducted between all three groups (CDAP vs. NC, CDAN vs. NC, and CDAP vs. CDAN). Results: In comparison with the NC group, the CDAP group showed reduced rCMglc predominantly in temporoparietal regions, whereas the CDAN group showed lower rCMglc in regions of the frontal lobe, in addition to the temporoparietal regions. The CDAN group also showed lower rCMglc in right anterior cingulate and left inferior orbitofrontal regions, in a comparison between the CDAP and CDAN groups. Limitations: The generalizability of the findings is limited because this study has a relatively small number of participants. In addition, this study used cross-sectional design rather than longitudinal design. Conclusions: Our findings may provide a reference to assess the risk of future cognitive deterioration. Consequently, this study is expected to contribute to prevention and early identification of dementia associated with AD.

Original language	English
Pages (from-to)	30-36
Number of pages	7
Journal	Journal of Affective Disorders
Volume	239
DOIs	https://doi.org/10.1016/j.jad.2018.06.029
Publication status	Published - 2018 Oct 15

Bibliographical note

Funding Information:
This project was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare , Republic of Korea ( HC15C1509 to HG Jeong) and the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT ( NRF-2015R1C1A1A01052172 to HG Jeong). The funding agency had no role in the design or conduct of the study; the collection, management, analysis, or interpretation of the data; or the preparation, review, or approval of the manuscript. In addition, it had no role in the decision to submit the article for publication.

Funding Information:
This project was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (HC15C1509 to HG Jeong) and the Brain Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT (NRF-2015R1C1A1A01052172 to HG Jeong). The funding agency had no role in the design or conduct of the study; the collection, management, analysis, or interpretation of the data; or the preparation, review, or approval of the manuscript. In addition, it had no role in the decision to submit the article for publication.

Publisher Copyright:
© 2018 Elsevier B.V.

Keywords

Alzheimer's disease
Amyloid
Depression
FDG-PET
Hypometabolism
Mild cognitive impairment

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jad.2018.06.029

Cite this

@article{39318841267c4f00b2afb4e2cee205f3,

title = "Regional glucose metabolism due to the presence of cerebral amyloidopathy in older adults with depression and mild cognitive impairment",

abstract = "Background: Depression is a risk factor for mild cognitive impairment (MCI) and for the conversion from MCI to Alzheimer's disease (AD). This study investigated regional cerebral glucose metabolism (rCMglc) in older adults with depression and MCI, either with or without amyloidopathy. Methods: We recruited 31 older adults diagnosed with depression and MCI, and 21 older adults with normal cognition (NC). All participants completed demographic questionnaires and were examined with a standardized neuropsychological battery, F-18 fluorodeoxyglucose positron emission tomography (PET), and F-18 florbetaben PET. We classified subjects with depression and MCI into amyloid-β-positive (CDAP; n = 16) and amyloid-β-negative (CDAN; n = 15) groups. Pairwise rCMglc analyses were conducted between all three groups (CDAP vs. NC, CDAN vs. NC, and CDAP vs. CDAN). Results: In comparison with the NC group, the CDAP group showed reduced rCMglc predominantly in temporoparietal regions, whereas the CDAN group showed lower rCMglc in regions of the frontal lobe, in addition to the temporoparietal regions. The CDAN group also showed lower rCMglc in right anterior cingulate and left inferior orbitofrontal regions, in a comparison between the CDAP and CDAN groups. Limitations: The generalizability of the findings is limited because this study has a relatively small number of participants. In addition, this study used cross-sectional design rather than longitudinal design. Conclusions: Our findings may provide a reference to assess the risk of future cognitive deterioration. Consequently, this study is expected to contribute to prevention and early identification of dementia associated with AD.",

keywords = "Alzheimer's disease, Amyloid, Depression, FDG-PET, Hypometabolism, Mild cognitive impairment",

author = "Youn, {Hyun Chul} and Lee, {Eun Seong} and Suji Lee and Sangil Suh and Jeong, {Hyun Ghang} and Eo, {Jae Seon}",

note = "Funding Information: This project was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare , Republic of Korea ( HC15C1509 to HG Jeong) and the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT ( NRF-2015R1C1A1A01052172 to HG Jeong). The funding agency had no role in the design or conduct of the study; the collection, management, analysis, or interpretation of the data; or the preparation, review, or approval of the manuscript. In addition, it had no role in the decision to submit the article for publication. Funding Information: This project was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (HC15C1509 to HG Jeong) and the Brain Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT (NRF-2015R1C1A1A01052172 to HG Jeong). The funding agency had no role in the design or conduct of the study; the collection, management, analysis, or interpretation of the data; or the preparation, review, or approval of the manuscript. In addition, it had no role in the decision to submit the article for publication. Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

year = "2018",

month = oct,

day = "15",

doi = "10.1016/j.jad.2018.06.029",

language = "English",

volume = "239",

pages = "30--36",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Regional glucose metabolism due to the presence of cerebral amyloidopathy in older adults with depression and mild cognitive impairment

AU - Youn, Hyun Chul

AU - Lee, Eun Seong

AU - Lee, Suji

AU - Suh, Sangil

AU - Jeong, Hyun Ghang

AU - Eo, Jae Seon

N1 - Funding Information: This project was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare , Republic of Korea ( HC15C1509 to HG Jeong) and the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT ( NRF-2015R1C1A1A01052172 to HG Jeong). The funding agency had no role in the design or conduct of the study; the collection, management, analysis, or interpretation of the data; or the preparation, review, or approval of the manuscript. In addition, it had no role in the decision to submit the article for publication. Funding Information: This project was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (HC15C1509 to HG Jeong) and the Brain Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT (NRF-2015R1C1A1A01052172 to HG Jeong). The funding agency had no role in the design or conduct of the study; the collection, management, analysis, or interpretation of the data; or the preparation, review, or approval of the manuscript. In addition, it had no role in the decision to submit the article for publication. Publisher Copyright: © 2018 Elsevier B.V.

PY - 2018/10/15

Y1 - 2018/10/15

N2 - Background: Depression is a risk factor for mild cognitive impairment (MCI) and for the conversion from MCI to Alzheimer's disease (AD). This study investigated regional cerebral glucose metabolism (rCMglc) in older adults with depression and MCI, either with or without amyloidopathy. Methods: We recruited 31 older adults diagnosed with depression and MCI, and 21 older adults with normal cognition (NC). All participants completed demographic questionnaires and were examined with a standardized neuropsychological battery, F-18 fluorodeoxyglucose positron emission tomography (PET), and F-18 florbetaben PET. We classified subjects with depression and MCI into amyloid-β-positive (CDAP; n = 16) and amyloid-β-negative (CDAN; n = 15) groups. Pairwise rCMglc analyses were conducted between all three groups (CDAP vs. NC, CDAN vs. NC, and CDAP vs. CDAN). Results: In comparison with the NC group, the CDAP group showed reduced rCMglc predominantly in temporoparietal regions, whereas the CDAN group showed lower rCMglc in regions of the frontal lobe, in addition to the temporoparietal regions. The CDAN group also showed lower rCMglc in right anterior cingulate and left inferior orbitofrontal regions, in a comparison between the CDAP and CDAN groups. Limitations: The generalizability of the findings is limited because this study has a relatively small number of participants. In addition, this study used cross-sectional design rather than longitudinal design. Conclusions: Our findings may provide a reference to assess the risk of future cognitive deterioration. Consequently, this study is expected to contribute to prevention and early identification of dementia associated with AD.

AB - Background: Depression is a risk factor for mild cognitive impairment (MCI) and for the conversion from MCI to Alzheimer's disease (AD). This study investigated regional cerebral glucose metabolism (rCMglc) in older adults with depression and MCI, either with or without amyloidopathy. Methods: We recruited 31 older adults diagnosed with depression and MCI, and 21 older adults with normal cognition (NC). All participants completed demographic questionnaires and were examined with a standardized neuropsychological battery, F-18 fluorodeoxyglucose positron emission tomography (PET), and F-18 florbetaben PET. We classified subjects with depression and MCI into amyloid-β-positive (CDAP; n = 16) and amyloid-β-negative (CDAN; n = 15) groups. Pairwise rCMglc analyses were conducted between all three groups (CDAP vs. NC, CDAN vs. NC, and CDAP vs. CDAN). Results: In comparison with the NC group, the CDAP group showed reduced rCMglc predominantly in temporoparietal regions, whereas the CDAN group showed lower rCMglc in regions of the frontal lobe, in addition to the temporoparietal regions. The CDAN group also showed lower rCMglc in right anterior cingulate and left inferior orbitofrontal regions, in a comparison between the CDAP and CDAN groups. Limitations: The generalizability of the findings is limited because this study has a relatively small number of participants. In addition, this study used cross-sectional design rather than longitudinal design. Conclusions: Our findings may provide a reference to assess the risk of future cognitive deterioration. Consequently, this study is expected to contribute to prevention and early identification of dementia associated with AD.

KW - Alzheimer's disease

KW - Amyloid

KW - Depression

KW - FDG-PET

KW - Hypometabolism

KW - Mild cognitive impairment

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U2 - 10.1016/j.jad.2018.06.029

DO - 10.1016/j.jad.2018.06.029

M3 - Article

C2 - 29991443

AN - SCOPUS:85049325837

SN - 0165-0327

VL - 239

SP - 30

EP - 36

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

ER -

Regional glucose metabolism due to the presence of cerebral amyloidopathy in older adults with depression and mild cognitive impairment

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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