Abstract
COVID-19, caused by SARS-CoV-2, has resulted in serious economic and health burdens. Current treatments remain inadequate to extinguish the epidemic, and efficient therapeutic approaches for COVID-19 are urgently being sought. Interestingly, accumulating evidence suggests that microenvironmental disorder plays an important role in the progression of COVID-19 in patients. In addition, recent advances in nanomaterial technologies provide promising opportunities for alleviating the altered homeostasis induced by a viral infection, providing new insight into COVID-19 treatment. Most literature reviews focus only on certain aspects of microenvironment alterations and fail to provide a comprehensive overview of the changes in homeostasis in COVID-19 patients. To fill this gap, this review systematically discusses alterations of homeostasis in COVID-19 patients and potential mechanisms. Next, advances in nanotechnology-based strategies for promoting homeostasis restoration are summarized. Finally, we discuss the challenges and prospects of using nanomaterials for COVID-19 management. This review provides a new strategy and insights into treating COVID-19 and other diseases associated with microenvironment disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 3638-3658 |
| Number of pages | 21 |
| Journal | Acta Pharmaceutica Sinica B |
| Volume | 13 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2023 Sept |
Bibliographical note
Publisher Copyright:© 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences
Keywords
- Altered homeostasis
- Coronavirus disease 19
- Microenvironment
- Microenvironmental disorder
- Nanomaterial technologies
- Nanotechnology
- Severe acute respiratory syndrome coronavirus 2
- Therapeutic approaches
ASJC Scopus subject areas
- General Pharmacology, Toxicology and Pharmaceutics