Regulating the microenvironment with nanomaterials: Potential strategies to ameliorate COVID-19

Zhicheng Liu, Zhuolei Han, Xin Jin, Jusung An, Jaewon Kim, Wenting Chen, Jong Seung Kim, Ji Zheng, Jun Deng

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


COVID-19, caused by SARS-CoV-2, has resulted in serious economic and health burdens. Current treatments remain inadequate to extinguish the epidemic, and efficient therapeutic approaches for COVID-19 are urgently being sought. Interestingly, accumulating evidence suggests that microenvironmental disorder plays an important role in the progression of COVID-19 in patients. In addition, recent advances in nanomaterial technologies provide promising opportunities for alleviating the altered homeostasis induced by a viral infection, providing new insight into COVID-19 treatment. Most literature reviews focus only on certain aspects of microenvironment alterations and fail to provide a comprehensive overview of the changes in homeostasis in COVID-19 patients. To fill this gap, this review systematically discusses alterations of homeostasis in COVID-19 patients and potential mechanisms. Next, advances in nanotechnology-based strategies for promoting homeostasis restoration are summarized. Finally, we discuss the challenges and prospects of using nanomaterials for COVID-19 management. This review provides a new strategy and insights into treating COVID-19 and other diseases associated with microenvironment disorders.

Original languageEnglish
Pages (from-to)3638-3658
Number of pages21
JournalActa Pharmaceutica Sinica B
Issue number9
Publication statusPublished - 2023 Sept

Bibliographical note

Publisher Copyright:
© 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences


  • Altered homeostasis
  • Coronavirus disease 19
  • Microenvironment
  • Microenvironmental disorder
  • Nanomaterial technologies
  • Nanotechnology
  • Severe acute respiratory syndrome coronavirus 2
  • Therapeutic approaches

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)


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