Regulation of angiogenesis and vascular permeability by src family kinases: Opportunities for therapeutic treatment of solid tumors

Serk In Park, Ami N. Shah, Jing Zhang, Gary E. Gallick

Research output: Contribution to journalReview articlepeer-review

58 Citations (Scopus)

Abstract

Aberrant expression or activation of protein tyrosine kinases, including Src and related Src family kinases, is a common occurrence in many human cancers, resulting in deregulation of expression of numerous mediators of cellular functions, including pro-angiogenic molecules. In addition, Src activation regulates vascular permeability of endothelial cells. How these processes contribute to tumor progression and metastasis are the subjects of this review. As Src-selective inhibitors have entered clinical trials for a number of solid tumors, further understanding of the roles of Src kinases in mediating tumor angiogenesis as well as modulating tumor/microenvironment interactions will provide insights into the best use of these inhibitors in treating patients afflicted with tumors in which Src is activated.

Original languageEnglish
Pages (from-to)1207-1217
Number of pages11
JournalExpert Opinion on Therapeutic Targets
Volume11
Issue number9
DOIs
Publication statusPublished - 2007 Sept
Externally publishedYes

Bibliographical note

Funding Information:
National Cancer Institute grant CA-16672 (GE Gallick), Lockton Foundation (GE Gallick), Gillson Longenbaugh Foundation (GE Gallick), National Institutes of Health T32 CA-09599 (AN Shah), the Eleanor B. Pillsbury Fellowship-University of Illinois Hospital (AN Shah) and the Sowell-Huggins Fellowship (J Zhang). GE Gallick is the Sowell-Huggins Professor of Cancer Biology.

Keywords

  • Angiogenesis
  • Metastasis
  • Protein tyrosine kinase
  • Src family kinase
  • Tumor progression
  • Tyrosine kinase inhibitors
  • VEGF
  • Vascular permeability

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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