Abstract
Both acute myeloid leukemia 1 and c-Fos are regulatory factors of hematopoietic cell differentiation. We identified that the c-fos promoter contains an acute myeloid leukemia 1 binding site at nucleotide positions -6-+14. c-fos promoter activity was induced by transient overexpression of acute myeloid leukemia 1 in Jurkat T-cells, but not by that of the short form of acute myeloid leukemia 1-MTG8, a chimeric acute myeloid leukemia 1 protein. In 32Dcl3 myeloid cells, stable overexpression of acute myeloid leukemia 1-MTG8 blocked the c-fos gene transcription and cell differentiation, but that of acute myeloid leukemia did not. These data suggest that acute myeloid leukemia 1 and acute myeloid leukemia 1-MTG8 reciprocally regulate the myeloid cell differentiation, possibly by the way of regulating c-fos gene transcription. Copyright (C) 1999 Federation of European Biochemical Societies.
Original language | English |
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Pages (from-to) | 86-90 |
Number of pages | 5 |
Journal | FEBS Letters |
Volume | 446 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1999 Mar 5 |
Externally published | Yes |
Keywords
- Acute myeloid leukemia 1
- Acute myeloid leukemia 1-MTG8
- Myeloid cell differentiation
- Transcription
- c-fos
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology