Regulation of IL-18 expression by CRH in mouse microglial cells

Yoolhee Yang; Eunsil Hahm; Youngin Kim; Jaeseung Kang; Wangjae Lee; Innoc Han; Pyungkeun Myung; Hyungsik Kang; Hyunjeong Park; Daeho Cho

doi:10.1016/j.imlet.2004.12.003

Regulation of IL-18 expression by CRH in mouse microglial cells

Yoolhee Yang
, Eunsil Hahm
, Youngin Kim
, Jaeseung Kang
, Wangjae Lee
, Innoc Han
, Pyungkeun Myung
, Hyungsik Kang
, Hyunjeong Park
, Daeho Cho^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Corticotropin releasing hormone (CRH) is a major regulator of the stress response. This study examined whether CRH regulates interleukin-18 expression on microglia, BV2. Our data show that CRH enhanced IL-18 expression and significantly induced the secretion of functional IL-18 protein. Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-l-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-18. Indeed, it was also found that CRH increased the generation of ROI. Taken together, these results indicate that CRH is an important mediator that regulates IL-18 expression in the brain during stress.

Original language	English
Pages (from-to)	291-296
Number of pages	6
Journal	Immunology Letters
Volume	98
Issue number	2
DOIs	https://doi.org/10.1016/j.imlet.2004.12.003
Publication status	Published - 2005 May 15
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by a Grant (No. R11-2002-100-03003) from ERC program of The Korea Science and Engineering Foundation.

Keywords

BV2
CRH
IL-18
Microglia
ROI

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.imlet.2004.12.003

Cite this

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title = "Regulation of IL-18 expression by CRH in mouse microglial cells",

abstract = "Corticotropin releasing hormone (CRH) is a major regulator of the stress response. This study examined whether CRH regulates interleukin-18 expression on microglia, BV2. Our data show that CRH enhanced IL-18 expression and significantly induced the secretion of functional IL-18 protein. Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-l-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-18. Indeed, it was also found that CRH increased the generation of ROI. Taken together, these results indicate that CRH is an important mediator that regulates IL-18 expression in the brain during stress.",

keywords = "BV2, CRH, IL-18, Microglia, ROI",

author = "Yoolhee Yang and Eunsil Hahm and Youngin Kim and Jaeseung Kang and Wangjae Lee and Innoc Han and Pyungkeun Myung and Hyungsik Kang and Hyunjeong Park and Daeho Cho",

note = "Funding Information: This work was supported by a Grant (No. R11-2002-100-03003) from ERC program of The Korea Science and Engineering Foundation.",

year = "2005",

month = may,

day = "15",

doi = "10.1016/j.imlet.2004.12.003",

language = "English",

volume = "98",

pages = "291--296",

journal = "Immunology Letters",

issn = "0165-2478",

publisher = "Elsevier B.V.",

number = "2",

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TY - JOUR

T1 - Regulation of IL-18 expression by CRH in mouse microglial cells

AU - Yang, Yoolhee

AU - Hahm, Eunsil

AU - Kim, Youngin

AU - Kang, Jaeseung

AU - Lee, Wangjae

AU - Han, Innoc

AU - Myung, Pyungkeun

AU - Kang, Hyungsik

AU - Park, Hyunjeong

AU - Cho, Daeho

N1 - Funding Information: This work was supported by a Grant (No. R11-2002-100-03003) from ERC program of The Korea Science and Engineering Foundation.

PY - 2005/5/15

Y1 - 2005/5/15

N2 - Corticotropin releasing hormone (CRH) is a major regulator of the stress response. This study examined whether CRH regulates interleukin-18 expression on microglia, BV2. Our data show that CRH enhanced IL-18 expression and significantly induced the secretion of functional IL-18 protein. Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-l-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-18. Indeed, it was also found that CRH increased the generation of ROI. Taken together, these results indicate that CRH is an important mediator that regulates IL-18 expression in the brain during stress.

AB - Corticotropin releasing hormone (CRH) is a major regulator of the stress response. This study examined whether CRH regulates interleukin-18 expression on microglia, BV2. Our data show that CRH enhanced IL-18 expression and significantly induced the secretion of functional IL-18 protein. Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-l-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-18. Indeed, it was also found that CRH increased the generation of ROI. Taken together, these results indicate that CRH is an important mediator that regulates IL-18 expression in the brain during stress.

KW - BV2

KW - CRH

KW - IL-18

KW - Microglia

KW - ROI

UR - https://www.scopus.com/pages/publications/20944433981

U2 - 10.1016/j.imlet.2004.12.003

DO - 10.1016/j.imlet.2004.12.003

M3 - Article

C2 - 15860230

AN - SCOPUS:20944433981

SN - 0165-2478

VL - 98

SP - 291

EP - 296

JO - Immunology Letters

JF - Immunology Letters

IS - 2

ER -

Regulation of IL-18 expression by CRH in mouse microglial cells

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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