Reirradiation with intensity-modulated radiation therapy for recurrent or secondary head and neck cancer: Meta-analysis and systematic review

Jeongshim Lee; In Soo Shin; Woo Chul Kim; Won Sup Yoon; Woong Sub Koom; Chai Hong Rim

doi:10.1002/hed.26264

Reirradiation with intensity-modulated radiation therapy for recurrent or secondary head and neck cancer: Meta-analysis and systematic review

Jeongshim Lee, In Soo Shin, Woo Chul Kim, Won Sup Yoon, Woong Sub Koom, Chai Hong Rim

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Background: To summarize outcomes of reirradiation with intensity-modulated radiotherapy (IMRT) for recurrent or secondary head and neck cancer (HNC). Methods: Primary endpoints were 2-year local control (LC) and overall survival (OS). Studies involving only recurrent nasopharyngeal patients with cancer were excluded. Results: A total of 17 studies involving 1635 patients were included. Fourteen (82%) of those were retrospective, and 15 (88%) were from single institution. Reirradiation with IMRT produced pooled 2-year LC and OS rates of 52% (95% confidence interval [CI], 46%-57%) and 46% (95% CI, 41%-50%), respectively. In subgroup analyses, the rate of salvage surgery (<42% vs ≥42%) influenced the pooled 2-year LC rate (45.9% vs 58.5%, P =.011). The pooled rates of late grade ≥ 3 and grade 5 toxicities were 26% (95% CI, 20%-32%) and 3.1% (95% CI, 2%-5%), respectively. Conclusions: Reirradiation with IMRT was an effective modality compared to historical outcomes in the pre-IMRT era.

Original language	English
Pages (from-to)	2473-2485
Number of pages	13
Journal	Head and Neck
Volume	42
Issue number	9
DOIs	https://doi.org/10.1002/hed.26264
Publication status	Published - 2020 Sept 1

Bibliographical note

Funding Information:
This work was supported by the Inha University Hospital Research Grant.

Funding Information:
This work was supported by the Inha University Hospital Research Grant.

Publisher Copyright:
© 2020 Wiley Periodicals, Inc.

Keywords

head and neck cancer
intensity-modulated radiotherapy
meta-analysis
recurrence
reirradiation

ASJC Scopus subject areas

Otorhinolaryngology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.26264

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title = "Reirradiation with intensity-modulated radiation therapy for recurrent or secondary head and neck cancer: Meta-analysis and systematic review",

abstract = "Background: To summarize outcomes of reirradiation with intensity-modulated radiotherapy (IMRT) for recurrent or secondary head and neck cancer (HNC). Methods: Primary endpoints were 2-year local control (LC) and overall survival (OS). Studies involving only recurrent nasopharyngeal patients with cancer were excluded. Results: A total of 17 studies involving 1635 patients were included. Fourteen (82%) of those were retrospective, and 15 (88%) were from single institution. Reirradiation with IMRT produced pooled 2-year LC and OS rates of 52% (95% confidence interval [CI], 46%-57%) and 46% (95% CI, 41%-50%), respectively. In subgroup analyses, the rate of salvage surgery (<42% vs ≥42%) influenced the pooled 2-year LC rate (45.9% vs 58.5%, P =.011). The pooled rates of late grade ≥ 3 and grade 5 toxicities were 26% (95% CI, 20%-32%) and 3.1% (95% CI, 2%-5%), respectively. Conclusions: Reirradiation with IMRT was an effective modality compared to historical outcomes in the pre-IMRT era.",

keywords = "head and neck cancer, intensity-modulated radiotherapy, meta-analysis, recurrence, reirradiation",

author = "Jeongshim Lee and Shin, {In Soo} and Kim, {Woo Chul} and Yoon, {Won Sup} and Koom, {Woong Sub} and Rim, {Chai Hong}",

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AU - Shin, In Soo

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AU - Yoon, Won Sup

AU - Koom, Woong Sub

AU - Rim, Chai Hong

N1 - Funding Information: This work was supported by the Inha University Hospital Research Grant. Funding Information: This work was supported by the Inha University Hospital Research Grant. Publisher Copyright: © 2020 Wiley Periodicals, Inc.

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N2 - Background: To summarize outcomes of reirradiation with intensity-modulated radiotherapy (IMRT) for recurrent or secondary head and neck cancer (HNC). Methods: Primary endpoints were 2-year local control (LC) and overall survival (OS). Studies involving only recurrent nasopharyngeal patients with cancer were excluded. Results: A total of 17 studies involving 1635 patients were included. Fourteen (82%) of those were retrospective, and 15 (88%) were from single institution. Reirradiation with IMRT produced pooled 2-year LC and OS rates of 52% (95% confidence interval [CI], 46%-57%) and 46% (95% CI, 41%-50%), respectively. In subgroup analyses, the rate of salvage surgery (<42% vs ≥42%) influenced the pooled 2-year LC rate (45.9% vs 58.5%, P =.011). The pooled rates of late grade ≥ 3 and grade 5 toxicities were 26% (95% CI, 20%-32%) and 3.1% (95% CI, 2%-5%), respectively. Conclusions: Reirradiation with IMRT was an effective modality compared to historical outcomes in the pre-IMRT era.

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Reirradiation with intensity-modulated radiation therapy for recurrent or secondary head and neck cancer: Meta-analysis and systematic review

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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